WormBase Tree Display for Gene: WBGene00010776
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WBGene00010776 | SMap | S_parent | Sequence | K11E4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | pix-1 | Person_evidence | WBPerson3660 | |||
WBPerson855 | |||||||
Sequence_name | K11E4.4 | ||||||
Molecular_name | K11E4.4a | ||||||
K11E4.4a.1 | |||||||
CE42239 | |||||||
K11E4.4b | |||||||
CE45486 | |||||||
K11E4.4b.1 | |||||||
Other_name | tag-207 | ||||||
CELE_K11E4.4 | Accession_evidence | NDB | BX284606 | ||||
Public_name | pix-1 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Split_into | WBGene00077679 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pix | ||||||
Allele (139) | |||||||
Strain | WBStrain00035952 | ||||||
WBStrain00036130 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (39) | |||||||
Paralog | WBGene00006496 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||
WBGene00006805 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00006887 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00009337 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00010111 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00015704 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | pix-1 is encodes a GTPase activator protein that forms a highly conserved signaling complex with GIT-1 and PAK, and interacts with Rac/CDC42 GTPases; pix-1 is orthologous to mammalian alpha-pix (OMIM: 300267); PIX-1 work together with GIT-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis, PIX-1, GIT-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; expressed in Z1/Z4 at L1 stage. PIX-1 is expressed in CeHDs and migrating DTCs. | Paper_evidence | WBPaper00032371 | |||
WBPaper00038193 | |||||||
Curator_confirmed | WBPerson12884 | ||||||
Date_last_updated | 12 Jul 2011 00:00:00 | ||||||
Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in anchoring junction; cell periphery; and cytoplasm. Expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Is an ortholog of human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||
Disease_info | Potential_model | DOID:1059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:685) | ||
Molecular_info | Corresponding_CDS | K11E4.4a | |||||
K11E4.4b | |||||||
Corresponding_CDS_history | K11E4.4:wp188 | ||||||
Corresponding_transcript | K11E4.4a.1 | ||||||
K11E4.4b.1 | |||||||
Other_sequence (12) | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result | WBRNAi00007314 | Inferred_automatically | RNAi_primary | |||
WBRNAi00050605 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr8757 | ||||||
Expr11073 | |||||||
Expr11813 | |||||||
Expr15283 | |||||||
Expr1014347 | |||||||
Expr1034716 | |||||||
Expr1154313 | |||||||
Expr2014943 | |||||||
Expr2033178 | |||||||
Drives_construct | WBCnstr00005767 | ||||||
WBCnstr00019251 | |||||||
WBCnstr00019465 | |||||||
WBCnstr00031155 | |||||||
Construct_product | WBCnstr00008105 | ||||||
WBCnstr00019251 | |||||||
WBCnstr00019252 | |||||||
WBCnstr00019465 | |||||||
WBCnstr00031155 | |||||||
Antibody | WBAntibody00002940 | ||||||
WBAntibody00002941 | |||||||
Microarray_results (24) | |||||||
Expression_cluster (75) | |||||||
Interaction (51) | |||||||
Map_info | Map | X | Position | 14.4983 | Error | 0.071335 | |
Positive | Positive_clone | K11E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4898 | |||||
4143 | |||||||
Pseudo_map_position | |||||||
Reference (21) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |