pix-1 is encodes a GTPase activator protein that forms a highly conserved signaling complex with GIT-1 and PAK, and interacts with Rac/CDC42 GTPases; pix-1 is orthologous to mammalian alpha-pix (OMIM: 300267); PIX-1 work together with GIT-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis, PIX-1, GIT-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; expressed in Z1/Z4 at L1 stage. PIX-1 is expressed in CeHDs and migrating DTCs.
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in anchoring junction; cell periphery; and cytoplasm. Expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Is an ortholog of human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.