WormBase Tree Display for Gene: WBGene00010776

WBGene00010776 SMap: S_parent: Sequence: K11E4
  Identity: Version: 3
    Name: CGC_name: pix-1 Person_evidence: WBPerson3660
            WBPerson855
      Sequence_name: K11E4.4
      Molecular_name: K11E4.4a
        K11E4.4a.1
        CE42239
        K11E4.4b
        CE45486
        K11E4.4b.1
      Other_name: tag-207
        CELE_K11E4.4 Accession_evidence: NDB BX284606
      Public_name: pix-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 15 Dec 2006 13:58:33 WBPerson1847 Name_change: CGC_name: pix-1
                Other_name: tag-207
        3 22 Feb 2008 08:59:15 WBPerson1983 Event: Split_into: WBGene00077679
      Split_into: WBGene00077679
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pix
    Allele (139)
    Strain: WBStrain00035952
      WBStrain00036130
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (39)
    Paralog: WBGene00006496 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006805 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006887 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009337 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00010111 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015704 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: pix-1 is encodes a GTPase activator protein that forms a highly conserved signaling complex with GIT-1 and PAK, and interacts with Rac/CDC42 GTPases; pix-1 is orthologous to mammalian alpha-pix (OMIM: 300267); PIX-1 work together with GIT-1 and PAK-1 independently of RAC/CDC-42 GTPases to control DTC migration during gonad morphogenesis; in epithelial morphogenesis, PIX-1, GIT-1 and PAK-1 together regulate intermediate-filament phosphorylation and CeHD biogenesis; Tension exerted by adjacent muscles or externally exerted mechanical pressure maintains GIT-1 at hemidesmosome and stimulates PAK-1 activity through PIX-1 and Rac; expressed in Z1/Z4 at L1 stage. PIX-1 is expressed in CeHDs and migrating DTCs. Paper_evidence: WBPaper00032371
            WBPaper00038193
          Curator_confirmed: WBPerson12884
          Date_last_updated: 12 Jul 2011 00:00:00
      Automated_description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in anchoring junction; cell periphery; and cytoplasm. Expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Is an ortholog of human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS292 version of WormBase
          Date_last_updated: 24 Apr 2024 00:00:00
  Disease_info: Potential_model: DOID:1059 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:685)
  Molecular_info: Corresponding_CDS: K11E4.4a
      K11E4.4b
    Corresponding_CDS_history: K11E4.4:wp188
    Corresponding_transcript: K11E4.4a.1
      K11E4.4b.1
    Other_sequence (12)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00007314 Inferred_automatically: RNAi_primary
      WBRNAi00050605 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr8757
      Expr11073
      Expr11813
      Expr15283
      Expr1014347
      Expr1034716
      Expr1154313
      Expr2014943
      Expr2033178
    Drives_construct: WBCnstr00005767
      WBCnstr00019251
      WBCnstr00019465
      WBCnstr00031155
    Construct_product: WBCnstr00008105
      WBCnstr00019251
      WBCnstr00019252
      WBCnstr00019465
      WBCnstr00031155
    Antibody: WBAntibody00002940
      WBAntibody00002941
    Microarray_results (24)
    Expression_cluster: WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041071:spe-44_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049626:UNC-75_target
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:SGP_biased
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060886:spr-5(by101)_upregulated
      WBPaper00061527:npp-8_4355-afd-1_4796
      WBPaper00061527:srj-42-srw-113
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00064992:Eugenol_downregulated
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      cgc4489_group_6
      WBPaper00025032:cluster_95
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_D
      WBPaper00036464:S.aureus-RN6390_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045294:50uM_TBBP_downregulated
      WBPaper00055899:nitroguanidine_regulated
    Interaction (51)
  Map_info: Map: X Position: 14.4983 Error: 0.071335
    Positive: Positive_clone: K11E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4898
        4143
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene