WormBase Tree Display for Variation: WBVar00091514
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WBVar00091514 | Evidence | Paper_evidence | WBPaper00027611 | |||||
---|---|---|---|---|---|---|---|---|
Name | Public_name | ok205 | ||||||
Sequence_details | Mapping_target | K03F8 | ||||||
SeqStatus | Pending_curation | |||||||
Variation_type | Allele | |||||||
Origin | Species | Caenorhabditis elegans | ||||||
Strain | WBStrain00028653 | |||||||
Laboratory | RB | |||||||
Person | WBPerson46 | |||||||
KO_consortium_allele | ||||||||
Status | Live | |||||||
Affects | Gene | WBGene00000044 | ||||||
Description | Phenotype | WBPhenotype:0000525 | Paper_evidence | WBPaper00041959 | ||||
Curator_confirmed | WBPerson557 | |||||||
Remark | Wild-type worms climb the nicotine gradient, that is worms approach the nicotine spot in a time- and concentration dependent manner. These mutants have reduced nicotine approach behavior. | Paper_evidence | WBPaper00041959 | |||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Worms placed on a nicotine gradient. The nicotine gradient was formed by adding 10 uL of 50 mm nicotine tartrate salt solution in water and allowed 90 minutes to diffuse. | Paper_evidence | WBPaper00041959 | ||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0001573 | Paper_evidence | WBPaper00041959 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | Wild-type worms climb the nicotine gradient, that is worms approach the nicotine spot in a time- and concentration dependent manner. These mutants have reduced nicotine approach behavior. | Paper_evidence | WBPaper00041959 | |||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Worms placed on a nicotine gradient. The nicotine gradient was formed by adding 10 uL of 50 mm nicotine tartrate salt solution in water and allowed 90 minutes to diffuse. | Paper_evidence | WBPaper00041959 | ||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0001780 | Paper_evidence | WBPaper00041959 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | acr-5 mutants were defective at associating the presence of nicotine with butanone under starvation conditions. Authors demonstrated that worms previously exposed to 50 mM nicotine in the presence of 100% butanone approached 0.5% butanone, whereas worms exposed to plates lacking nicotine in the presence of 100% butanone later avoided 0.5% butanone. acr- 5 mutants, which blocked approach to nicotine, also eliminated the ability of nicotine to preserve approach to butanone by mutants in butanone. | Paper_evidence | WBPaper00041959 | |||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Authors demonstrated that worms previously exposed to 50 mM nicotine in the presence of 100% butanone approached 0.5% butanone, whereas worms exposed to plates lacking nicotine in the presence of 100% butanone later avoided 0.5% butanone. | Paper_evidence | WBPaper00041959 | ||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_not_observed | WBPhenotype:0000643 | Paper_evidence | WBPaper00041959 | |||||
Curator_confirmed | WBPerson557 | |||||||
WBPhenotype:0000681 | Paper_evidence | WBPaper00027611 | ||||||
Curator_confirmed | WBPerson712 | |||||||
Remark | Scored as DMPP sensitive. | Paper_evidence | WBPaper00027611 | |||||
Curator_confirmed | WBPerson712 | |||||||
Affected_by | Molecule | WBMol:00000896 | Paper_evidence | WBPaper00027611 | ||||
Curator_confirmed | WBPerson712 | |||||||
WBPhenotype:0001468 | Paper_evidence | WBPaper00041959 | ||||||
Curator_confirmed | WBPerson557 | |||||||
Remark | Mutant worms exhibited a normal approach to a benzaldehyde stimulus. | Paper_evidence | WBPaper00041959 | |||||
Curator_confirmed | WBPerson557 | |||||||
Phenotype_assay | Treatment | Worms placed on chemotaxis plates spotted with 0.01% benzaldehyde. | Paper_evidence | WBPaper00041959 | ||||
Curator_confirmed | WBPerson557 | |||||||
Reference | WBPaper00041959 | |||||||
WBPaper00027611 | ||||||||
Remark | Last updated on 29 Nov 2002 | |||||||
Generated by the C. elegans Gene Knockout Consortium | ||||||||
Method | KO_consortium_allele |