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WormBase Tree Display for Variation: WBVar00088388

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Name Class

WBVar00088388EvidenceAuthor_evidenceDe Bono M
NamePublic_nameky13
Other_nameC39E6.6.1:c.181C>T
CE06941:p.Gln61Ter
HGVSgCHROMOSOME_X:g.4769358G>A
Sequence_detailsSMapS_parentSequenceC39E6
Flanking_sequencesctgtgaattatcattaaatttcagagcgttaaaacatattcattctgaacctggcggcga
Mapping_targetC39E6
Type_of_mutationSubstitutionct
SeqStatusSequenced
Variation_typeAllele
OriginSpeciesCaenorhabditis elegans
StrainWBStrain00005261
LaboratoryCX
StatusLive
AffectsGeneWBGene00003807
TranscriptC39E6.6.1VEP_consequencestop_gained
VEP_impactHIGH
HGVScC39E6.6.1:c.181C>T
HGVSpCE06941:p.Gln61Ter
cDNA_position192
CDS_position181
Protein_position61
Exon_number3/11
Codon_changeCaa/Taa
Amino_acid_changeQ/*
InteractorWBInteraction000520368
WBInteraction000524561
WBInteraction000563597
GeneticsInterpolated_map_positionX-6.64648
DescriptionPhenotypeWBPhenotype:0000016Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Remark% animals paralyzed after 60 min on 1mM aldicarb was significantly higher than % N2 animals paralyzed.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00003650Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0007833PATO:0001549Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000420Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Remark% animals paralyzed after 60 min on 200mM levamisole was significantly higher than % N2 animals paralyzed under same conditions.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Affected_byMoleculeWBMol:00004019Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000655Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkRate of endogenous IPSCs (53%) were significantly decreased compared to wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0000660Paper_evidenceWBPaper00005511
WBPaper00003187
Curator_confirmedWBPerson2021
WBPerson712
RemarkSocial feeders aggregated within 20 min of being placed on a fresh food source. Increasing population density in the presence of food, stimulated aggregation in npr-1 strainsPaper_evidenceWBPaper00005511
Curator_confirmedWBPerson2021
Animals exhibited striking clumping behavior on food. In order of pPaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00005511
WBPaper00003187
Curator_confirmedWBPerson2021
WBPerson712
EQ_annotationsLife_stageWBls:0000041PATO:0000460Paper_evidenceWBPaper00005511
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentAnimals were assayed on a bacterial lawn.Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
WBPhenotype:0000662Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
RemarkAnimals moved twice as fast as N2 in the presence of food, although in the absence of food, animals moved at a speed indistinguishable from N2. Strength of hyperactivity on food ad609 > ky13, n1353 > g320.Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
WBPhenotype:0001013Paper_evidenceWBPaper00032196
WBPaper00032501
Curator_confirmedWBPerson712
WBPerson2021
RemarkAnimals were more susceptible to infection by P. aeruginosa, S. enterica and E. faecalis than N2 animals.Paper_evidenceWBPaper00032196
Curator_confirmedWBPerson712
npr-1 alleles had enhanced susceptibility to killing by PA14Paper_evidenceWBPaper00032501
Curator_confirmedWBPerson2021
Variation_effectNullPaper_evidenceWBPaper00032501
Curator_confirmedWBPerson2021
Phenotype_assayStrainWBStrain00005261Paper_evidenceWBPaper00032196
Curator_confirmedWBPerson712
WBPhenotype:0001273Paper_evidenceWBPaper00038142
Curator_confirmedWBPerson712
RemarkMutants had significantly higher thermal thresholds than wild-type N2 worms.Paper_evidenceWBPaper00038142
Curator_confirmedWBPerson712
WBPhenotype:0001319Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkRate of endogenous IPSCs were significantly decreased (53%) compared to wild-type.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001765Paper_evidenceWBPaper00031935
WBPaper00031936
Curator_confirmedWBPerson712
WBPerson2021
RemarkAnimals showed reduced avoidance to 5% carbon dioxide both in the presence and absence of food.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
A hypomorphic mutation in npr-1 in an N2 background results in reduced CO2 avoidancePaper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Variation_effectProbable_null_via_phenotypePaper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
Hypomorph_reduction_of_functionPaper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
EQ_annotationsLife_stageWBls:0000057PATO:0000460Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_assayTreatmentStrains were maintained at 22C.Paper_evidenceWBPaper00031935
Curator_confirmedWBPerson712
10% CO2Paper_evidenceWBPaper00031936
Curator_confirmedWBPerson2021
Phenotype_not_observedWBPhenotype:0000637Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
RemarkAnimals did not appear to have any defects in dauer formation.Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
RecessivePaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
Variation_effectNullPaper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
Phenotype_assayTreatmentAnimals were assayed on a bacterial lawn.Paper_evidenceWBPaper00003187
Curator_confirmedWBPerson712
WBPhenotype:0000847Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkThe density of GFP::SNB-1 puncta in GABAergic axons was unaltered compared to N2Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
EQ_annotationsAnatomy_termWBbt:0005190PATO:0000460Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
Phenotype_assayGenotypePunc-129::GFP::SNB-1Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001320Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
RemarkIPSC amplitudes were normal.Paper_evidenceWBPaper00031872
Curator_confirmedWBPerson712
WBPhenotype:0001991Paper_evidenceWBPaper00034694
Curator_confirmedWBPerson2857
Remarkanimals enter into hypoxia-induced reproductive and developmental diapause same as wild-typePaper_evidenceWBPaper00034694
Curator_confirmedWBPerson2857
Reference (16)
MethodSubstitution_allele