WormBase Tree Display for Transgene: WBTransgene00005879
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| WBTransgene00005879 | Public_name | WBPaper00034765Ex2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Summary | [snb-1p:: G85R hSOD1::YFP] | |||||||
| Construction | Construct | WBCnstr00005747 | ||||||
| Construction_summary | A PCR-amplified genomic DNA segment extending from minus 3021 bp to just upstream of the SNB start codon, was inserted in place of the unc-54 enhancer/promoter in the plasmid pPD30_38, and the various human SOD cDNA-containing segments were then adjoined. | |||||||
| Genetic_information | Extrachromosomal | |||||||
| Phenotype | WBPhenotype:0000017 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | G85R-YFP animals were strongly resistant to aldicarb as compared with the corresponding wild-type animals | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Affected_by | Molecule | WBMol:00003650 | Paper_evidence | WBPaper00034765 | ||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000039 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Reduced survival | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000154 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Reduced brood size | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000273 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Side-to-side thrashing movement in liquid was severely affected in G85R SOD YFP transgenic animals | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0000674 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | Slow rate of development | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0001405 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | G85R-YFP exhibited a well-demarcated pattern, suggestive of aggregate formation. Aggregates were directly observed by EM, which revealed well-delineated electron-dense inclusions in the cytosol of ventral nerve cord cell bodies of G85R-YFP animals | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| WBPhenotype:0004025 | Paper_evidence | WBPaper00034765 | ||||||
| Curator_confirmed | WBPerson2021 | |||||||
| Remark | There was markedly slower movement in the G85R YFP animals | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Caused_by_other | Human SOD1 | Paper_evidence | WBPaper00034765 | |||||
| Curator_confirmed | WBPerson2021 | |||||||
| Reference | WBPaper00034765 | |||||||
| Species | Caenorhabditis elegans |
