WormBase Tree Display for Strain: WBStrain00050599
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WBStrain00050599 | Status | Live | |||||
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Public_name | JMT61 | ||||||
Properties | Phenotype | WBPhenotype:0001171 | Paper_evidence | WBPaper00062543 | |||
Curator_confirmed | WBPerson712 | ||||||
Remark | "We found that both aakg-1; aakg-2; aakg-3 and aakg-4; aakg-5 mutants had shorter lifespans than WT (Figure 1D, p<0.001 and p<0.01, respectively), but that the effect was most pronounced in the aakg-1; aakg-2; aakg-3 mutant. Notably, the lifespan of aakg-1; aakg-2; aakg-3 triple mutants is similar to that reported for C. elegans lacking aak-2 (Figure 1D), implying that disruption of aakg-1, -2, and-3 (and thereby AMP-sensitive regulation) effectively mimics the removal of the subunit, at least in terms of WT lifespan (Apfeld et al. 2004; McQuary et al. 2016)." | Paper_evidence | WBPaper00062543 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0001349 | Paper_evidence | WBPaper00062543 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | " Thr172 phosphorylation was almost undetectable in aakg-1; aakg-2; aakg-3 triple mutants, indicating that this family of aakg isoforms is required to induce phosphorylation of the subunit." | Paper_evidence | WBPaper00062543 | ||||
Curator_confirmed | WBPerson712 | ||||||
Phenotype_not_observed | WBPhenotype:0000154 | Paper_evidence | WBPaper00062543 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | "...despite its dramatic impact on lifespan, combined mutation of aakg-1, aakg-2, and aakg-3 did not alter C. elegans brood size." | Paper_evidence | WBPaper00062543 | ||||
Curator_confirmed | WBPerson712 | ||||||
Location | JMT | ||||||
Remark | [2022-03-05T19:12:35.759Z WBPerson712] New Strain: 10.17912/micropub.biology.000534 aakg-1(syb409); aakg-2(syb410); aakg-3(syb411) | Curator_confirmed | WBPerson712 | ||||
Reference | WBPaper00062543 | ||||||
Species | Caenorhabditis elegans |