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WormBase Tree Display for Strain: WBStrain00050599

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Name Class

WBStrain00050599StatusLive
Public_nameJMT61
PropertiesPhenotypeWBPhenotype:0001171Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
Remark"We found that both aakg-1; aakg-2; aakg-3 and aakg-4; aakg-5 mutants had shorter lifespans than WT (Figure 1D, p<0.001 and p<0.01, respectively), but that the effect was most pronounced in the aakg-1; aakg-2; aakg-3 mutant. Notably, the lifespan of aakg-1; aakg-2; aakg-3 triple mutants is similar to that reported for C. elegans lacking aak-2 (Figure 1D), implying that disruption of aakg-1, -2, and-3 (and thereby AMP-sensitive regulation) effectively mimics the removal of the subunit, at least in terms of WT lifespan (Apfeld et al. 2004; McQuary et al. 2016)."Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
WBPhenotype:0001349Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
Remark" Thr172 phosphorylation was almost undetectable in aakg-1; aakg-2; aakg-3 triple mutants, indicating that this family of aakg isoforms is required to induce phosphorylation of the subunit."Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000154Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
Remark"...despite its dramatic impact on lifespan, combined mutation of aakg-1, aakg-2, and aakg-3 did not alter C. elegans brood size."Paper_evidenceWBPaper00062543
Curator_confirmedWBPerson712
LocationJMT
Remark[2022-03-05T19:12:35.759Z WBPerson712] New Strain: 10.17912/micropub.biology.000534 aakg-1(syb409); aakg-2(syb410); aakg-3(syb411)Curator_confirmedWBPerson712
ReferenceWBPaper00062543
SpeciesCaenorhabditis elegans