WormBase Tree Display for Gene: WBGene00044684

WBGene00044684 SMap: S_parent: Sequence: T08G11
  Identity: Version: 2
    Name: Sequence_name: T08G11.2
      Molecular_name: T08G11.2
        T08G11.2.1
        CE13445
      Other_name: CELE_T08G11.2 Accession_evidence: NDB BX284601
      Public_name: T08G11.2
    DB_info: Database: AceView gene 1J494
        WormQTL gene WBGene00044684
        WormFlux gene WBGene00044684
        NDB locus_tag CELE_T08G11.2
        Panther gene CAEEL|WormBase=WBGene00044684|UniProtKB=Q94011
          family PTHR31128
        NCBI gene 191630
        RefSeq protein NM_060001.3
        TREEFAM TREEFAM_ID TF315835
        TrEMBL UniProtAcc Q94011
        UniProt_GCRP UniProtAcc Q94011
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Jul 2004 09:37:00 WBPerson1971 Event: Created
        2 29 Nov 2005 09:49:28 WBPerson2970 Event: Split_into: WBGene00001198
      Split_from: WBGene00001198
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (24)
    Strain: WBStrain00037279
    RNASeq_FPKM (74)
    Ortholog (32)
    Paralog: WBGene00009321 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009643 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00009705 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00013590 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00015034 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00015820 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020377 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: T08G11.2 encodes a nematode-specific sperm protein, required for a normally high ovulation rate, that interacts with EGL-32; despite not being EGL-32, and although T08G11.2(tm336) complements egl-32(n155), T08G11.2 can partially rescue egl-32 mutants when expressed transgenically, implying that T08G11.2 can be a nonorthologous replacement for EGL-32 function in vivo; T08G11.2 has an SH2 motif, but this motif lacks a critical arginine residue; T08G11.2 has no obvious non-nematode homologs, but is paralogous to four other C. elegans proteins (B0207.11, F42G4.6, F44F4.10, and Y81G3A.1); T08G11.2(tm336) hermaphrodites have a lowered ovulation rate (and thus a lowered rate of egg-laying), retaining significantly fewer eggs than wild-type, yet also retaining late-stage embryos; T08G11.2 has no obvious phenotype in mass RNAi experiments, possibly because of genetic redundancy with its paralogs; T08G11.2 expression is strongly enriched in spermatogenesis. Paper_evidence: WBPaper00006390
            WBPaper00029335
          Curator_confirmed: WBPerson567
          Date_last_updated: 23 Jul 2007 00:00:00
      Automated_description: Enriched in PHshL; excretory gland cell; germ line; and in male based on proteomic; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including swsn-2.2; numr-2; and numr-1 based on microarray and RNA-seq studies. Is affected by seventeen chemicals including ethanol; methylmercuric chloride; and manganese chloride based on RNA-seq and microarray studies. Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Molecular_info: Corresponding_CDS: T08G11.2
    Corresponding_transcript: T08G11.2.1
    Other_sequence: Tcir_isotig09215
      CBC00238_1
      Tcir_isotig11832
    Associated_feature: WBsf220006
  Experimental_info: RNAi_result: WBRNAi00004173 Inferred_automatically: RNAi_primary
      WBRNAi00052880 Inferred_automatically: RNAi_primary
      WBRNAi00035360 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012572
      Expr1156478
      Expr2024222
    Drives_construct: WBCnstr00023399
    Construct_product: WBCnstr00023399
    Microarray_results (18)
    Expression_cluster (169)
    Interaction (171)
  Map_info: Positive: Positive_clone: T08G11 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: I 3.31043
  Reference: WBPaper00010526
    WBPaper00018512
    WBPaper00018762
    WBPaper00029335
  Remark: egl-32 was previously connected to T08G11.2 based on rescue and RNAi phenotypes. Subsequently, no mutation in T08G11.2 from egl-32 mutants have been found thus egl-32 and T08G11.2 may be interacting loci Person_evidence: WBPerson551
  Method: Gene