WormBase Tree Display for Gene: WBGene00021983
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| WBGene00021983 | SMap | S_parent | Sequence | Y58G8A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | npr-5 | Paper_evidence | WBPaper00033064 | |||||
| Person_evidence | WBPerson2441 | ||||||||
| Sequence_name | Y58G8A.4 | ||||||||
| Molecular_name | Y58G8A.4a | ||||||||
| Y58G8A.4a.1 | |||||||||
| CE33345 | |||||||||
| Y58G8A.4b | |||||||||
| CE36962 | |||||||||
| Y58G8A.4b.1 | |||||||||
| Other_name | CELE_Y58G8A.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | npr-5 | ||||||||
| DB_info | Database | AceView | gene | 5A756 | |||||
| WormQTL | gene | WBGene00021983 | |||||||
| WormFlux | gene | WBGene00021983 | |||||||
| NDB | locus_tag | CELE_Y58G8A.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00021983|UniProtKB=Q6F3C9 | |||||||
| family | PTHR24235 | ||||||||
| NCBI | gene | 190386 | |||||||
| RefSeq | protein | NM_001029093.5 | |||||||
| NM_001029094.5 | |||||||||
| TREEFAM | TREEFAM_ID | TF350004 | |||||||
| TrEMBL | UniProtAcc | H2KZY4 | |||||||
| Q6F3C9 | |||||||||
| UniProt_GCRP | UniProtAcc | Q6F3C9 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:05 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 Dec 2011 16:46:04 | WBPerson2970 | Name_change | CGC_name | npr-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | npr | ||||||||
| Allele (108) | |||||||||
| Strain | WBStrain00032091 | ||||||||
| WBStrain00000310 | |||||||||
| WBStrain00005331 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (37) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | Y58G8A.4 encodes, by alternative splicing, two isoforms of a receptor activated by FLP-18; in cell culture, Y58G8A.4 is bound and activated by FLP-18 peptides with nanomolar affinity, and acts primarily through Gq-alpha signalling in vitro (i.e., probably through EGL-30 in vivo); Y58G8A.4 is paralogous to NPR-1 (and many other C. elegans receptors), and homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; other neuropeptides from Ascaris suum (AF3, AF4, and AF20), which share a C-terminal sequence with FLP-18, also activate Y58G8A.4; Y58G8A.4 has no obvious phenotype in mass RNAi assays. | Paper_evidence | WBPaper00030992 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 29 Dec 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Involved in regulation of muscle contraction. Predicted to be located in neuron projection and plasma membrane. Expressed in body wall musculature; chemosensory neurons; and head neurons. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4464) | ||||
| Molecular_info | Corresponding_CDS | Y58G8A.4a | |||||||
| Y58G8A.4b | |||||||||
| Corresponding_CDS_history | Y58G8A.4:wp93 | ||||||||
| Y58G8A.4:wp126 | |||||||||
| Corresponding_transcript | Y58G8A.4a.1 | ||||||||
| Y58G8A.4b.1 | |||||||||
| Other_sequence (15) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00057734 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00057735 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8976 | ||||||||
| Expr16102 | |||||||||
| Expr16103 | |||||||||
| Expr1027787 | |||||||||
| Expr1039667 | |||||||||
| Expr1161159 | |||||||||
| Expr2014425 | |||||||||
| Expr2032666 | |||||||||
| Drives_construct | WBCnstr00013649 | ||||||||
| WBCnstr00018590 | |||||||||
| WBCnstr00018591 | |||||||||
| WBCnstr00024376 | |||||||||
| WBCnstr00042763 | |||||||||
| Construct_product | WBCnstr00018591 | ||||||||
| WBCnstr00024376 | |||||||||
| WBCnstr00042763 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction | WBInteraction000559823 | ||||||||
| WBInteraction000559825 | |||||||||
| WBInteraction000559834 | |||||||||
| WBInteraction000564507 | |||||||||
| WBInteraction000564522 | |||||||||
| WBInteraction000564527 | |||||||||
| WBInteraction000564533 | |||||||||
| WBInteraction000564541 | |||||||||
| Map_info | Map | V | Position | -20.0049 | |||||
| Positive | Positive_clone | Y58G8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
