WormBase Tree Display for Gene: WBGene00020140

WBGene00020140 SMap: S_parent: Sequence: T01B11
  Identity: Version: 5
    Name: CGC_name: ant-1.4 Paper_evidence: WBPaper00031899
          Person_evidence: WBPerson1746
      Sequence_name: T01B11.4
      Molecular_name: T01B11.4
        T01B11.4.1
        CE12898
      Other_name: tag-316 Person_evidence: WBPerson201
        ant-1.44
        wan-3 Paper_evidence: WBPaper00033159
        CELE_T01B11.4 Accession_evidence: NDB BX284604
      Public_name: ant-1.4
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 22 Apr 2005 11:55:18 WBPerson2970 Name_change: CGC_name: tag-316
        3 04 Jun 2008 11:48:40 WBPerson2970 Name_change: CGC_name: ant-1.44
                Other_name: tag-316
        4 21 Nov 2008 12:07:43 WBPerson2970 Name_change: CGC_name: ant-1.4
                Other_name: ant-1.44
        5 03 Mar 2014 14:12:13 WBPerson2970 Name_change: Other_name: wan-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ant
    Allele (27)
    Strain: WBStrain00002772
      WBStrain00003162
      WBStrain00035562
      WBStrain00035953
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (63)
    Paralog (35)
    Structured_description: Concise_description: ant-1.4 encodes an ortholog of the human adenine nucleotide translocase ANT genes, the other ANT genes in C. elegans include ant-1.1, ant-1.2 and ant-1.3; phylogenetic analysis indicates that ant-1.4 is specific to C. elegans, resulting from a recent duplication following the speciation of the common ancestor of C. elegans, C. briggsae, and C. remanei; by homology, ANT-1.4 is predicted to mediate the exchange of ATP generated in the mitochondria for cytosolic ADP; ANT-1.4 GFP fusion protein is expressed in a pair of head neurons, amphid socket and sheath cells and in a few body-wall muscle and vulval muscle cells. Paper_evidence: WBPaper00031899
          Curator_confirmed: WBPerson324
          Date_last_updated: 25 Apr 2011 00:00:00
      Automated_description: Predicted to enable ATP:ADP antiporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in mitochondrion. Expressed in amphid sensillum; body wall musculature; rectal gland cell; somatic nervous system; and vulval muscle. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2; facioscapulohumeral muscular dystrophy; intrinsic cardiomyopathy (multiple); and mitochondrial DNA depletion syndrome (multiple). Is an ortholog of human SLC25A4 (solute carrier family 25 member 4); SLC25A5 (solute carrier family 25 member 5); and SLC25A6 (solute carrier family 25 member 6). Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:0110429 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:0080335 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:699 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:11727 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:0111517 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:12558 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
      DOID:0080130 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10990)
  Molecular_info: Corresponding_CDS: T01B11.4
    Corresponding_transcript: T01B11.4.1
    Other_sequence (220)
    Associated_feature: WBsf997225
      WBsf1017849
      WBsf230431
  Experimental_info: RNAi_result: WBRNAi00114334 Inferred_automatically: RNAi_primary
      WBRNAi00017930 Inferred_automatically: RNAi_primary
      WBRNAi00071429 Inferred_automatically: RNAi_primary
      WBRNAi00052073 Inferred_automatically: RNAi_primary
      WBRNAi00034996 Inferred_automatically: RNAi_primary
      WBRNAi00114330 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00003299
      WBCnstr00004572
      WBCnstr00013119
      WBCnstr00037822
    Construct_product: WBCnstr00013119
      WBCnstr00037822
    Microarray_results (15)
    Expression_cluster (240)
    Interaction (88)
  Map_info: Map: IV Position: 3.81996 Error: 0.003005
    Positive: Positive_clone: T01B11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5212
    Pseudo_map_position
  Reference: WBPaper00031039
    WBPaper00031899
    WBPaper00038491
    WBPaper00055090
    WBPaper00062518
    WBPaper00066405
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene