WormBase Tree Display for Gene: WBGene00017103
expand all nodes | collapse all nodes | view schema
| WBGene00017103 | SMap | S_parent | Sequence | E02H9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | klo-2 | Paper_evidence | WBPaper00037943 | |||||
| Person_evidence | WBPerson1735 | ||||||||
| Sequence_name | E02H9.5 | ||||||||
| Molecular_name | E02H9.5 | ||||||||
| E02H9.5.1 | |||||||||
| CE09122 | |||||||||
| Other_name | CELE_E02H9.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | klo-2 | ||||||||
| DB_info | Database | AceView | gene | 3D533 | |||||
| WormQTL | gene | WBGene00017103 | |||||||
| WormFlux | gene | WBGene00017103 | |||||||
| NDB | locus_tag | CELE_E02H9.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00017103|UniProtKB=Q9TZA0 | |||||||
| family | PTHR10353 | ||||||||
| NCBI | gene | 184000 | |||||||
| RefSeq | protein | NM_001381778.1 | |||||||
| TrEMBL | UniProtAcc | Q9TZA0 | |||||||
| UniProt_GCRP | UniProtAcc | Q9TZA0 | |||||||
| OMIM | gene | 603202 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Jan 2011 10:01:10 | WBPerson2970 | Name_change | CGC_name | klo-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klo | ||||||||
| Allele (106) | |||||||||
| Strain | WBStrain00032221 | ||||||||
| WBStrain00032245 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00101653 | ||||||||
| 00101654 | |||||||||
| 00101655 | |||||||||
| 00126504 | |||||||||
| 00126505 | |||||||||
| Ortholog (50) | |||||||||
| Paralog | WBGene00016848 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | klo-2 encodes a homolog of the human beta-glucosidase-like proteins KL (klotho; OMIM:604824), KLB (beta-klotho; OMIM:611135), GBA3 (cytosolic beta-glucosidase; OMIM:606619), LCT (lactase-phlorizin hydrolase; OMIM:603202, variant in adult lactose tolerance), and LCTL (lactase-like protein); KLO-2 has 76% identity (364/478 residues) to its paralog encoded by klo-1; perhaps due to genetic redundancy, klo-2 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00031047 | |||||
| WBPaper00031048 | |||||||||
| WBPaper00031049 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson1843 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Jan 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Expressed in hypodermis and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including congenital lactase deficiency; end stage renal disease; and intracranial embolism. Is an ortholog of human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:557 | Homo sapiens | Paper_evidence | WBPaper00037943 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Mar 2021 00:00:00 | ||||||||
| Potential_model | DOID:783 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | |||||
| DOID:0111646 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6530) | ||||||
| DOID:4372 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:2247 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:784 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6344) | ||||||
| Models_disease_asserted | WBDOannot00000891 | ||||||||
| Molecular_info | Corresponding_CDS | E02H9.5 | |||||||
| Corresponding_transcript | E02H9.5.1 | ||||||||
| Other_sequence | Oden_isotig16624 | ||||||||
| Oden_isotig19714 | |||||||||
| Oden_isotig16625 | |||||||||
| FC553985.1 | |||||||||
| Associated_feature | WBsf991521 | ||||||||
| WBsf991522 | |||||||||
| WBsf1014408 | |||||||||
| WBsf224508 | |||||||||
| WBsf224509 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr9182 | ||||||||
| Expr1012486 | |||||||||
| Expr1147607 | |||||||||
| Expr2012954 | |||||||||
| Expr2031186 | |||||||||
| Drives_construct | WBCnstr00008196 | ||||||||
| WBCnstr00008311 | |||||||||
| WBCnstr00008312 | |||||||||
| WBCnstr00008313 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (12) | |||||||||
| Map_info | Map | III | Position | -14.479 | Error | 0.029859 | |||
| Positive | Positive_clone | E02H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00037595 | ||||||||
| WBPaper00037943 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00043922 | |||||||||
| WBPaper00054932 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061277 | |||||||||
| WBPaper00061925 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
