WormBase Tree Display for Gene: WBGene00013976
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| WBGene00013976 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | hizr-1 | Person_evidence | WBPerson341 | |||||
| Sequence_name | ZK455.6 | ||||||||
| Molecular_name | ZK455.6 | ||||||||
| ZK455.6.1 | |||||||||
| CE43818 | |||||||||
| Other_name | nhr-33 | Person_evidence | WBPerson600 | ||||||
| CELE_ZK455.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | hizr-1 | ||||||||
| DB_info | Database | AceView | gene | XL939 | |||||
| WormQTL | gene | WBGene00013976 | |||||||
| WormFlux | gene | WBGene00013976 | |||||||
| NDB | locus_tag | CELE_ZK455.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00013976|UniProtKB=G5ED47 | |||||||
| family | PTHR46011 | ||||||||
| NCBI | gene | 191322 | |||||||
| RefSeq | protein | NM_077492.7 | |||||||
| SwissProt | UniProtAcc | G5ED47 | |||||||
| TREEFAM | TREEFAM_ID | TF315401 | |||||||
| UniProt_GCRP | UniProtAcc | G5ED47 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:55 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 29 Nov 2016 11:06:22 | WBPerson2970 | Name_change | Other_name | nhr-33 | ||||
| 3 | 29 Nov 2016 11:06:22 | WBPerson2970 | Name_change | CGC_name | hizr-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hizr | ||||||||
| Allele (53) | |||||||||
| Strain | WBStrain00040587 | ||||||||
| WBStrain00040588 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (28) | |||||||||
| Paralog (217) | |||||||||
| Structured_description | Concise_description | hizr-1, the high-zinc-activated nuclear receptor, encodes a nuclear receptor transcription factor that has an evolutionarily conserved DNA-binding domain and ligand-binding domain; HIZR-1 is both necessary and sufficient to activate transcription of endogenous zinc-homeostasis genes in response to high dietary zinc; furthermore, HIZR-1 is necessary for growth and development when animals are exposed to high levels of zinc; the ligand binding domain directly binds zinc, which promotes nuclear accumulation and activation of the protein; the DNA-binding domain directly binds the HZA enhancer, which mediates transcriptional activation of multiple genes involved in zinc homeostasis. | Paper_evidence | WBPaper00050830 | |||||
| Person_evidence | WBPerson10390 | ||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Apr 2017 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in intracellular zinc ion homeostasis and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK455.6 | |||||||
| Corresponding_CDS_history | ZK455.6:wp188 | ||||||||
| ZK455.6:wp204 | |||||||||
| Corresponding_transcript | ZK455.6.1 | ||||||||
| Other_sequence (12) | |||||||||
| Transcription_factor | WBTranscriptionFactor000619 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00022017 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00059436 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr13323 | ||||||||
| Expr1018542 | |||||||||
| Expr1162863 | |||||||||
| Expr1200143 | |||||||||
| Expr2012488 | |||||||||
| Expr2030727 | |||||||||
| Drives_construct | WBCnstr00039190 | ||||||||
| Construct_product | WBCnstr00016791 | ||||||||
| WBCnstr00039190 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (82) | |||||||||
| Interaction (29) | |||||||||
| Map_info | Map | X | Position | 2.94481 | Error | 0.017092 | |||
| Positive | Positive_clone | ZK455 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5397 | |||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
