WormBase Tree Display for Gene: WBGene00013223
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| WBGene00013223 | SMap | S_parent | Sequence | Y55D9A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | efa-6 | Person_evidence | WBPerson75 | |||||
| WBPerson3760 | |||||||||
| Sequence_name | Y55D9A.1 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_Y55D9A.1 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | efa-6 | ||||||||
| DB_info | Database | AceView | gene | 4N370 | |||||
| WormQTL | gene | WBGene00013223 | |||||||
| WormFlux | gene | WBGene00013223 | |||||||
| NDB | locus_tag | CELE_Y55D9A.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00013223|UniProtKB=G5EET6 | |||||||
| family | PTHR10663 | ||||||||
| NCBI | gene | 178217 | |||||||
| RefSeq | protein | NM_001268723.3 | |||||||
| NM_070016.7 | |||||||||
| NM_001129346.3 | |||||||||
| NM_070015.7 | |||||||||
| SwissProt | UniProtAcc | G5EET6 | |||||||
| TREEFAM | TREEFAM_ID | TF319755 | |||||||
| UniProt_GCRP | UniProtAcc | G5EET6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 09 Mar 2007 09:55:43 | WBPerson2970 | Name_change | CGC_name | efa-6 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | efa | ||||||||
| Allele (164) | |||||||||
| Strain | WBStrain00033218 | ||||||||
| WBStrain00062567 | |||||||||
| WBStrain00062565 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Contained_in_operon | CEOP4524 | ||||||||
| Ortholog (52) | |||||||||
| Paralog | WBGene00012386 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00019726 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001743 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00007703 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008685 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | efa-6 encodes a putative guanine nucleotide exchange factor that inhibits DHC-1 in vivo; EFA-6's human orthologs are the pleckstrin and Sec7 domain proteins PSD/TYL/cytohesin-1 (OMIM:602327), PSD2, PSD3, and PSD4; efa-6(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that EFA-6 negatively regulates dynein; EFA-6 is localized to nonpolarized cell cortex in oocytes and early one-cell zygotes, to anterior cell cortex in one-cell embryos after pseudocleavage, and to the interface of AB and P1 blastomeres, subsequently disappearing in four-cell embryos; EFA-6 has a central Sec7 domain predicted to activate guanine-nucleotide exchange in ARF1, and a C-terminal pleckstrin-homology domain predicted to activate the Sec7 domain when binding phosphatidylinositol. | Paper_evidence | WBPaper00028540 | |||||
| WBPaper00028541 | |||||||||
| WBPaper00028542 | |||||||||
| WBPaper00028543 | |||||||||
| WBPaper00028544 | |||||||||
| WBPaper00028545 | |||||||||
| WBPaper00030897 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 26 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including mitotic nuclear membrane disassembly; regulation of cellular component organization; and regulation of mitotic centrosome separation. Located in cell cortex; microtubule minus-end; and plasma membrane. Expressed in U.la; U.lp; and linker cell. Is an ortholog of human PSD (pleckstrin and Sec7 domain containing). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y55D9A.1a | |||||||
| Y55D9A.1b | |||||||||
| Y55D9A.1c | |||||||||
| Y55D9A.1d | |||||||||
| Corresponding_transcript | Y55D9A.1a.1 | ||||||||
| Y55D9A.1b.1 | |||||||||
| Y55D9A.1c.1 | |||||||||
| Y55D9A.1d.1 | |||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf668439 | ||||||||
| WBsf668440 | |||||||||
| WBsf717196 | |||||||||
| WBsf998170 | |||||||||
| WBsf998171 | |||||||||
| WBsf998172 | |||||||||
| WBsf1018398 | |||||||||
| WBsf1018399 | |||||||||
| WBsf231047 | |||||||||
| WBsf231048 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00057517 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00098432 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021023 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065625 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000921 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr4803 | ||||||||
| Expr4807 | |||||||||
| Expr12438 | |||||||||
| Expr14766 | |||||||||
| Expr15080 | |||||||||
| Expr1012726 | |||||||||
| Expr1035882 | |||||||||
| Expr1160952 | |||||||||
| Expr2011184 | |||||||||
| Expr2029420 | |||||||||
| Drives_construct | WBCnstr00041418 | ||||||||
| WBCnstr00041991 | |||||||||
| Construct_product (14) | |||||||||
| Regulate_expr_cluster | WBPaper00056039:efa-6(tm3124)_downregulated | ||||||||
| WBPaper00056039:efa-6(tm3124)_upregulated | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | IV | Position | 6.10269 | Error | 0.007518 | |||
| Positive | Positive_clone | Y55D9A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
