WormBase Tree Display for Gene: WBGene00011908
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| WBGene00011908 | SMap | S_parent | Sequence | T22A3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pash-1 | Person_evidence | WBPerson490 | |||||
| Sequence_name | T22A3.5 | ||||||||
| Molecular_name | T22A3.5a | ||||||||
| T22A3.5a.1 | |||||||||
| CE48538 | |||||||||
| T22A3.5b | |||||||||
| CE48740 | |||||||||
| T22A3.5b.1 | |||||||||
| Other_name | CELE_T22A3.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | pash-1 | ||||||||
| DB_info | Database | AceView | gene | 1L181 | |||||
| WormQTL | gene | WBGene00011908 | |||||||
| WormFlux | gene | WBGene00011908 | |||||||
| OMIM | disease | 611867 | |||||||
| gene | 609030 | ||||||||
| NDB | locus_tag | CELE_T22A3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00011908|UniProtKB=U4PRH5 | |||||||
| family | PTHR13482 | ||||||||
| NCBI | gene | 172950 | |||||||
| RefSeq | protein | NM_001306533.3 | |||||||
| NM_001306532.2 | |||||||||
| TrEMBL | UniProtAcc | U4PEM4 | |||||||
| U4PRH5 | |||||||||
| UniProt_GCRP | UniProtAcc | U4PRH5 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 04 Nov 2004 11:21:33 | WBPerson2970 | Name_change | CGC_name | pash-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pash | ||||||||
| Allele (90) | |||||||||
| Strain | WBStrain00028979 | ||||||||
| WBStrain00034645 | |||||||||
| WBStrain00050747 | |||||||||
| WBStrain00050761 | |||||||||
| WBStrain00050760 | |||||||||
| WBStrain00052586 | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (35) | |||||||||
| Structured_description | Concise_description | pash-1 encodes an RNA-binding protein that is orthologous to Drosophila Pasha and mammalian DGCR8; pash-1 activity is required for processing of primary miRNA transripts (pri-miRNAs), such as that of let-7, to generate pre-miRNAs that will then be processed by DCR-1 to generate mature miRNAs; accordingly, pash-1 mutants show defects in let-7-mediated developmental processes, namely the transition from late larval to adult cell fates. | Paper_evidence | WBPaper00024573 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 May 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Involved in primary miRNA processing and regulation of developmental process. Predicted to be part of microprocessor complex. Expressed in head; hypodermis; intestine; marginal cell; and pharyngeal muscle cell. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in alcohol dependence. Is an ortholog of human DGCR8 (DGCR8 microprocessor complex subunit). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Sep 2018 00:00:00 | ||||||||
| Potential_model | DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2847) | |||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including DGCR8 (DGCR8 microprocessor complex subunit, also called DiGeorge syndrome critical region gene 8); both human DGCR8 and the C. elegans ortholog pash-1, are involoved in primary microRNA processing and thus microRNA maturation and microRNA-mediated gene regulation; knockdown phenotypes of pash-1 include reduced microRNA processing, decreased life-span, enhanced locomotor defects of the Unc phenotype and vulva defects. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| WBPaper00041677 | |||||||||
| WBPaper00024573 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 609030 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000372 | ||||||||
| Molecular_info | Corresponding_CDS | T22A3.5a | |||||||
| T22A3.5b | |||||||||
| Corresponding_CDS_history | T22A3.5:wp239 | ||||||||
| Corresponding_transcript | T22A3.5a.1 | ||||||||
| T22A3.5b.1 | |||||||||
| Other_sequence | CJC09477_1 | ||||||||
| CJC07777_1 | |||||||||
| CBC10852_1 | |||||||||
| CBC09698_1 | |||||||||
| EL889867.1 | |||||||||
| Associated_feature | WBsf643702 | ||||||||
| WBsf985045 | |||||||||
| WBsf218464 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr11294 | ||||||||
| Expr1017527 | |||||||||
| Expr1035253 | |||||||||
| Expr1157325 | |||||||||
| Expr2014747 | |||||||||
| Expr2032981 | |||||||||
| Drives_construct | WBCnstr00018744 | ||||||||
| WBCnstr00030293 | |||||||||
| Construct_product | WBCnstr00017327 | ||||||||
| WBCnstr00030293 | |||||||||
| Antibody | WBAntibody00002679 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (162) | |||||||||
| Interaction | WBInteraction000049918 | ||||||||
| WBInteraction000050732 | |||||||||
| WBInteraction000164470 | |||||||||
| WBInteraction000502008 | |||||||||
| WBInteraction000519133 | |||||||||
| WBInteraction000520386 | |||||||||
| WBInteraction000575441 | |||||||||
| Anatomy_function | WBbtf0565 | ||||||||
| WBbtf0566 | |||||||||
| WBbtf0567 | |||||||||
| WBbtf0568 | |||||||||
| WBbtf0569 | |||||||||
| WBbtf0570 | |||||||||
| WBProcess | WBbiopr:00000057 | ||||||||
| WBbiopr:00000081 | |||||||||
| Map_info | Map | I | Position | 5.05848 | Error | 0.000319 | |||
| Positive | Positive_clone | T22A3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5599 | |||||||
| 5267 | |||||||||
| 5545 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
