WormBase Tree Display for Gene: WBGene00010493

WBGene00010493 SMap: S_parent: Sequence: K02B9
  Identity: Version: 2
    Name: CGC_name: meg-2 Person_evidence: WBPerson4009
            WBPerson2290
      Sequence_name: K02B9.2
      Molecular_name: K02B9.2
        K02B9.2.1
        CE35572
      Other_name: CELE_K02B9.2 Accession_evidence: NDB BX284606
      Public_name: meg-2
    DB_info: Database: AceView gene XO542
        WormQTL gene WBGene00010493
        WormFlux gene WBGene00010493
        NDB locus_tag CELE_K02B9.2
        NCBI gene 181501
        RefSeq protein NM_077917.5
        SwissProt UniProtAcc Q21127
        UniProt_GCRP UniProtAcc Q21127
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Feb 2008 15:37:46 WBPerson2970 Name_change: CGC_name: meg-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: meg
    Allele (78)
    Strain: WBStrain00032280
    RNASeq_FPKM (74)
    GO_annotation: 00072912
      00072913
      00072914
      00072915
    Contained_in_operon: CEOPX165
    Ortholog: chrX_pilon.g20493 Caenorhabditis elegans From_analysis: WormBase-Compara
    Paralog: WBGene00010492 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: meg-2 encodes a novel protein that localizes exclusively to P granules; originally identified by microarray analyses of germline-enriched transcripts, loss of meg-2 activity by itself results in no obvious abnormalities, but loss of meg-2 activity in meg-1 mutant animals indicates that meg-1 and meg-2 likely have redundant functions in germline development; meg-2 may also function redundantly with mes-1; meg-2 expression in the proximal germline is positively regulated by MPK-1, the C. elegans MAP kinase ortholog; a GFP::MEG-2 fusion protein localizes exclusively to P granules in the embryonic germ cell lineage. Paper_evidence: WBPaper00028788
            WBPaper00031440
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 Mar 2008 00:00:00
      Automated_description: Involved in P granule disassembly. Located in P granule. Expressed in germ line. Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Molecular_info: Corresponding_CDS: K02B9.2
    Corresponding_CDS_history: K02B9.2:wp109
    Corresponding_transcript: K02B9.2.1
    Associated_feature: WBsf654543
      WBsf1007768
      WBsf1007769
      WBsf1007770
      WBsf1024323
      WBsf238180
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr7958
      Expr1018816
      Expr1034583
      Expr1153402
      Expr2013509
      Expr2031743
    Drives_construct: WBCnstr00031379
    Construct_product: WBCnstr00031379
    Regulate_expr_cluster: WBPaper00064559:meg-1(vr10)meg-2(RNAi)_downregulated
      WBPaper00064559:meg-1(vr10)meg-2(RNAi)_upregulated
    Microarray_results (17)
    Expression_cluster (195)
    Interaction (48)
  Map_info: Map: X Position: 15.3389 Error: 0.044108
    Positive: Positive_clone: K02B9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00010795
    WBPaper00031440
    WBPaper00036884
    WBPaper00038112
    WBPaper00046196
    WBPaper00064559
    WBPaper00067033
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene