WormBase Tree Display for Gene: WBGene00009813
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WBGene00009813 | SMap | S_parent | Sequence | F47B10 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | haly-1 | Paper_evidence | WBPaper00038278 | |||||
Person_evidence | WBPerson341 | ||||||||
Sequence_name | F47B10.2 | ||||||||
Molecular_name | F47B10.2 | ||||||||
F47B10.2.1 | |||||||||
CE03352 | |||||||||
Other_name | CELE_F47B10.2 | Accession_evidence | NDB | BX284606 | |||||
Public_name | haly-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
2 | 12 Apr 2011 11:48:32 | WBPerson2970 | Name_change | CGC_name | haly-1 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | haly | ||||||||
Allele (44) | |||||||||
Strain | WBStrain00040582 | ||||||||
WBStrain00040583 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Ortholog (30) | |||||||||
Structured_description | Concise_description | haly-1 encodes a histidine ammonia lyase orthologous to the human gene HISTIDASE (HAL; OMIM:235800); HALY-1 is required in C. elegans for conversion of histidine to urocanic acid via reductive deamination; loss-of-function mutations in haly-1 result in protection against zinc and nickel toxicity owing to increased levels of metal-chelating histidine; genetic studies suggest that haly-1 functions in parallel to members of the cation diffusion facilitator family of zinc transporters encodes by cdf-1, cdf-2, and sur-7 to modulate zinc sensitivity; haly-1 mRNA levels do not vary under different dietary zinc conditions. | Paper_evidence | WBPaper00031911 | |||||
WBPaper00038278 | |||||||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
WBPerson1843 | |||||||||
Date_last_updated | 04 Apr 2011 00:00:00 | ||||||||
Automated_description | Predicted to enable histidine ammonia-lyase activity. Involved in histidine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in histidinemia. Is an ortholog of human HAL (histidine ammonia-lyase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0060168 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4806) | ||||
Molecular_info | Corresponding_CDS | F47B10.2 | |||||||
Corresponding_transcript | F47B10.2.1 | ||||||||
Other_sequence (79) | |||||||||
Associated_feature | WBsf654368 | ||||||||
WBsf237907 | |||||||||
WBsf237908 | |||||||||
Experimental_info | RNAi_result | WBRNAi00015146 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00047595 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00032403 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram1244 | ||||||||
Expr6096 | |||||||||
Expr1025610 | |||||||||
Expr1034288 | |||||||||
Expr1151431 | |||||||||
Expr2012363 | |||||||||
Expr2030599 | |||||||||
Drives_construct | WBCnstr00003174 | ||||||||
WBCnstr00020173 | |||||||||
WBCnstr00031899 | |||||||||
Construct_product | WBCnstr00020173 | ||||||||
WBCnstr00031899 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (225) | |||||||||
Interaction (19) | |||||||||
Map_info | Map | X | Position | 2.67922 | |||||
Positive | Positive_clone | F47B10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference | WBPaper00031911 | ||||||||
WBPaper00038278 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00039078 | |||||||||
WBPaper00045887 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00063976 | |||||||||
WBPaper00064232 | |||||||||
WBPaper00065140 | |||||||||
WBPaper00065331 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |