WormBase Tree Display for Gene: WBGene00009671
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| WBGene00009671 | SMap | S_parent | Sequence | F43G9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mfap-1 | Person_evidence | WBPerson2495 | |||||
| WBPerson268 | |||||||||
| Sequence_name | F43G9.10 | ||||||||
| Molecular_name | F43G9.10 | ||||||||
| F43G9.10.1 | |||||||||
| CE10372 | |||||||||
| Other_name | CELE_F43G9.10 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | mfap-1 | ||||||||
| DB_info | Database | AceView | gene | 1J216 | |||||
| WormQTL | gene | WBGene00009671 | |||||||
| WormFlux | gene | WBGene00009671 | |||||||
| NDB | locus_tag | CELE_F43G9.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00009671|UniProtKB=Q93712 | |||||||
| family | PTHR15327 | ||||||||
| NCBI | gene | 172661 | |||||||
| RefSeq | protein | NM_059939.9 | |||||||
| SwissProt | UniProtAcc | Q93712 | |||||||
| TREEFAM | TREEFAM_ID | TF314398 | |||||||
| UniProt_GCRP | UniProtAcc | Q93712 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 02 Feb 2009 12:24:54 | WBPerson2970 | Name_change | CGC_name | mfap-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mfap | ||||||||
| Allele (17) | |||||||||
| Strain | WBStrain00027480 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00089623 | ||||||||
| 00089624 | |||||||||
| 00089625 | |||||||||
| 00089626 | |||||||||
| 00089627 | |||||||||
| 00089628 | |||||||||
| 00089629 | |||||||||
| 00089630 | |||||||||
| 00089631 | |||||||||
| Ortholog (13) | |||||||||
| Structured_description | Concise_description | mfap-1 encodes the C. elegans ortholog of the highly conserved mammalian microfibrillar-association protein1 (MFAP1); in C. elegans, MFAP-1 regulates alternative splicing and is essential for development; targets of MFAP-1 regulation include tos-1; MFAP-1 interacts with a number of protein in yeast two-hybrid screens including the products of K04G7.11 and D1054.14 that also encode presumptive splicing factors; mfap-1 is expressed in body wall muscles, the intestine, pharynx, and vulval muscles; in body wall muscle cells, MFAP-1 localizes to the nucleus; expression of human MFAP1 in C. elegans body wall muscles rescues the suppression of the unc-93 uncoordinated (rubberband) phenotype by C. elegans mfap-1 indicating that the function of MFAP-1 is conserved from nematodes to humans. | Paper_evidence | WBPaper00041328 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 26 Jul 2012 00:00:00 | ||||||||
| Automated_description | Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Expressed in body wall musculature; intestine; pharynx; and vulval muscle. Is an ortholog of human MFAP1 (microfibril associated protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F43G9.10 | |||||||
| Corresponding_transcript | F43G9.10.1 | ||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf649405 | ||||||||
| WBsf219955 | |||||||||
| Experimental_info | RNAi_result (35) | ||||||||
| Expr_pattern | Expr10144 | ||||||||
| Expr1020343 | |||||||||
| Expr1034227 | |||||||||
| Expr1151076 | |||||||||
| Expr2013545 | |||||||||
| Expr2031779 | |||||||||
| Drives_construct | WBCnstr00015492 | ||||||||
| WBCnstr00019916 | |||||||||
| WBCnstr00032007 | |||||||||
| Construct_product | WBCnstr00019916 | ||||||||
| WBCnstr00032007 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (129) | |||||||||
| Interaction (18) | |||||||||
| Map_info | Map | I | Position | 3.01369 | Error | 0.000276 | |||
| Positive | Positive_clone | F43G9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00034880 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040897 | |||||||||
| WBPaper00041328 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061662 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
