WormBase Tree Display for Gene: WBGene00007194
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| WBGene00007194 | SMap | S_parent | Sequence | B0491 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | dph-5 | Person_evidence | WBPerson3778 | |||||
| Sequence_name | B0491.7 | ||||||||
| Molecular_name | B0491.7 | ||||||||
| B0491.7.1 | |||||||||
| CE02109 | |||||||||
| Other_name | CELE_B0491.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | dph-5 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:47 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 11 Jun 2021 18:11:09 | WBPerson1983 | Name_change | CGC_name | dph-5 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | dph | ||||||||
| Allele (22) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00060454 | ||||||||
| 00060455 | |||||||||
| 00060456 | |||||||||
| 00060457 | |||||||||
| 00060458 | |||||||||
| 00119427 | |||||||||
| 00119428 | |||||||||
| 00119429 | |||||||||
| Contained_in_operon | CEOP2532 | ||||||||
| Ortholog (32) | |||||||||
| Structured_description | Concise_description | B0491.7 encodes a putative diphthine synthase orthologous to S. cerevisiae DPH5; DPH5 is an S-adenosylmethionine:EF-2 methyltransferase required for the enzymatic conversion of 3-amino-3-carboxypropyl-histidine to diphthine; DPH5 adds at least the last two of the three methyl groups present in diphthine, and is homologous to bacterial AdoMet:uroporphyrinogen III methyltransferases. | Paper_evidence | WBPaper00005654 | |||||
| WBPaper00012895 | |||||||||
| WBPaper00013419 | |||||||||
| WBPaper00013534 | |||||||||
| WBPaper00013537 | |||||||||
| WBPaper00013539 | |||||||||
| WBPaper00013556 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable diphthine methyl ester synthase activity and diphthine synthase activity. Predicted to be involved in methylation and protein histidyl modification to diphthamide. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Is an ortholog of human DPH5 (diphthamide biosynthesis 5). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070479 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24270) | ||||
| Molecular_info | Corresponding_CDS | B0491.7 | |||||||
| Corresponding_transcript | B0491.7.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf989723 | ||||||||
| WBsf989724 | |||||||||
| WBsf1013217 | |||||||||
| WBsf1013218 | |||||||||
| WBsf222128 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00061719 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00039105 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009805 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028169 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1026360 | ||||||||
| Expr1033100 | |||||||||
| Expr1143263 | |||||||||
| Expr2000207 | |||||||||
| Expr2018427 | |||||||||
| Drives_construct | WBCnstr00033929 | ||||||||
| Construct_product | WBCnstr00033929 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (120) | |||||||||
| SAGE_tag | SAGE:aatgcagttggctgttg | Strand | Sense | ||||||
| Unambiguously_mapped | |||||||||
| SAGE:tcgacttcca | Strand | Antisense | |||||||
| SAGE:ttggaaactttcaggcc | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| SAGE:ttggaaactt | Strand | Sense | |||||||
| Unambiguously_mapped | |||||||||
| Interaction (88) | |||||||||
| Map_info | Map | II | Position | 3.45336 | |||||
| Positive | Positive_clone | B0491 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00038491 | ||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
