WormBase Tree Display for Gene: WBGene00006815
expand all nodes | collapse all nodes | view schema
WBGene00006815 | SMap | S_parent | Sequence | W01A11 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-83 | Person_evidence | WBPerson261 | |||||
Sequence_name | W01A11.3 | ||||||||
Molecular_name (11) | |||||||||
Other_name | CeGrip | ||||||||
CELE_W01A11.3 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | unc-83 | ||||||||
DB_info | Database | WormQTL | gene | WBGene00006815 | |||||
WormFlux | gene | WBGene00006815 | |||||||
OMIM | disease | 610743 | |||||||
612998 | |||||||||
NDB | locus_tag | CELE_W01A11.3 | |||||||
NCBI | gene | 179033 | |||||||
RefSeq | protein | NM_001392533.1 | |||||||
NM_001392532.1 | |||||||||
NM_001083280.3 | |||||||||
SwissProt | UniProtAcc | Q23064 | |||||||
TREEFAM | TREEFAM_ID | TF352677 | |||||||
TrEMBL | UniProtAcc | Q0PDL1 | |||||||
G8JYF1 | |||||||||
UniProt_GCRP | UniProtAcc | Q23064 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143983 | ||||||||
Allele (315) | |||||||||
Legacy_information | e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)). | ||||||||
See also e1408, e1409, n159, n1216, n1217, n1218 | |||||||||
[C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT] | |||||||||
Strain | WBStrain00026512 | ||||||||
WBStrain00037609 | |||||||||
WBStrain00037683 | |||||||||
WBStrain00004325 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (26) | |||||||||
Ortholog (26) | |||||||||
Structured_description | Concise_description | unc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations. | Paper_evidence (6) | ||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 23 Apr 2010 00:00:00 | ||||||||
Automated_description | Enables dynein light chain binding activity. Involved in several processes, including egg-laying behavior; protein localization to nuclear envelope; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||
Accession_evidence | OMIM | 612998 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 14 Feb 2013 00:00:00 | ||||||||
Disease_relevance | Studies in elegans have contributed much to the knowledge of SUN-KASH protein complexes which link components of the nucleus to the cytoplasm; KASH domain proteins in elegans are involved in nuclear positioning and migration; the family of mammalian KASH (klarsicht, ANC-1 and Syne) domain proteins include Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
Accession_evidence | OMIM | 612998 | |||||||
610743 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 19 Mar 2012 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000051 | ||||||||
Molecular_info | Corresponding_CDS | W01A11.3a | |||||||
W01A11.3b | |||||||||
W01A11.3c | |||||||||
Corresponding_CDS_history | W01A11.3:wp162 | ||||||||
Corresponding_transcript | W01A11.3a.1 | ||||||||
W01A11.3b.1 | |||||||||
W01A11.3b.2 | |||||||||
W01A11.3c.1 | |||||||||
W01A11.3c.2 | |||||||||
Other_sequence (22) | |||||||||
Associated_feature (57) | |||||||||
Experimental_info | RNAi_result | WBRNAi00090325 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062672 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090007 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00054484 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00065283 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00054483 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089756 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090166 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062671 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00019442 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram318 | ||||||||
Expr1789 | |||||||||
Expr6810 | |||||||||
Expr13170 | |||||||||
Expr1023585 | |||||||||
Expr1032880 | |||||||||
Expr1158032 | |||||||||
Expr2017912 | |||||||||
Expr2036048 | |||||||||
Drives_construct | WBCnstr00002621 | ||||||||
Antibody | WBAntibody00000447 | ||||||||
WBAntibody00002169 | |||||||||
Microarray_results (31) | |||||||||
Expression_cluster (172) | |||||||||
Interaction (107) | |||||||||
Map_info | Map | V | Position | -0.105154 | Error | 0.00884 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf32 | |||||||
nDf1 | |||||||||
nDf18 | |||||||||
nDf33 | |||||||||
Positive_clone | W01A11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | 2_point | 311 | |||||||
Multi_point | 141 | ||||||||
142 | |||||||||
653 | |||||||||
657 | |||||||||
658 | |||||||||
5590 | |||||||||
Pos_neg_data | 843 | ||||||||
1735 | |||||||||
1748 | |||||||||
6813 | |||||||||
6814 | |||||||||
Reference (78) | |||||||||
Method | Gene |