WormBase Tree Display for Gene: WBGene00006812
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WBGene00006812 | SMap | S_parent | Sequence | F25C8 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | unc-80 | Person_evidence | WBPerson261 | |||
Sequence_name | F25C8.3 | ||||||
Molecular_name (15) | |||||||
Other_name | CELE_F25C8.3 | Accession_evidence | NDB | BX284605 | |||
Public_name | unc-80 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00009105 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143879 | ||||||
Allele (316) | |||||||
Legacy_information | e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069). | ||||||
See also e1069, e1272 | |||||||
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW] | |||||||
Strain | WBStrain00032777 | ||||||
WBStrain00040621 | |||||||
WBStrain00004238 | |||||||
WBStrain00004286 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Ortholog (35) | |||||||
Structured_description | Concise_description | unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. | Paper_evidence | WBPaper00001281 | |||
WBPaper00031000 | |||||||
WBPaper00031592 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 22 Jun 2010 00:00:00 | ||||||
Automated_description | Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||
Disease_info | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26582) | ||
Molecular_info | Corresponding_CDS | F25C8.3a | |||||
F25C8.3b | |||||||
F25C8.3c | |||||||
F25C8.3d | |||||||
F25C8.3e | |||||||
Corresponding_CDS_history | F25C8.3:wp87 | ||||||
F25C8.3:wp109 | |||||||
F25C8.3a:wp182 | |||||||
Corresponding_transcript | F25C8.3a.1 | ||||||
F25C8.3b.1 | |||||||
F25C8.3c.1 | |||||||
F25C8.3d.1 | |||||||
F25C8.3e.1 | |||||||
Other_sequence (25) | |||||||
Associated_feature | WBsf647771 | ||||||
WBsf662284 | |||||||
WBsf662285 | |||||||
WBsf662286 | |||||||
WBsf1003660 | |||||||
WBsf1003661 | |||||||
WBsf1003662 | |||||||
WBsf1022024 | |||||||
WBsf1022025 | |||||||
WBsf1022026 | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern | Expr4994 | ||||||
Expr8059 | |||||||
Expr8061 | |||||||
Expr16166 | |||||||
Expr1026757 | |||||||
Expr1032878 | |||||||
Expr1149400 | |||||||
Expr2017910 | |||||||
Expr2036046 | |||||||
Drives_construct | WBCnstr00000610 | ||||||
WBCnstr00001622 | |||||||
WBCnstr00013085 | |||||||
WBCnstr00042790 | |||||||
Construct_product | WBCnstr00000610 | ||||||
Microarray_results (26) | |||||||
Expression_cluster (207) | |||||||
Interaction (41) | |||||||
Map_info | Map | V | Position | 25.581 | Error | 0.021198 | |
Positive | Positive_clone | F25C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 1568 | |||||
Reference (46) | |||||||
Method | Gene |