WormBase Tree Display for Gene: WBGene00006802
expand all nodes | collapse all nodes | view schema
WBGene00006802 | SMap | S_parent | Sequence | T07A5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | unc-69 | Paper_evidence | WBPaper00027646 | |||||
Person_evidence | WBPerson261 | ||||||||
Sequence_name | T07A5.6 | ||||||||
Molecular_name | T07A5.6a | ||||||||
T07A5.6a.1 | |||||||||
CE23955 | |||||||||
T07A5.6b | |||||||||
CE38102 | |||||||||
T07A5.6c | |||||||||
CE41450 | |||||||||
T07A5.6b.1 | |||||||||
T07A5.6c.1 | |||||||||
Other_name | CELE_T07A5.6 | Accession_evidence | NDB | BX284603 | |||||
Public_name | unc-69 | ||||||||
DB_info | Database (9) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 30 Oct 2007 10:02:14 | WBPerson2970 | Event | Acquires_merge | WBGene00044098 | ||||
Name_change | Sequence_name | T07A5.6 | |||||||
Acquires_merge | WBGene00044098 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143321 | ||||||||
Allele (19) | |||||||||
Legacy_information | e587 : medium coiler inactive small; abnormalities in VD and DD commissures. ES3 ME0. NA2 (e602). | ||||||||
[C.elegansII] e587 : medium coiler, inactive, small; abnormalities in VD and DD commissures, longitudinal axon elongation. ES3 ME0. OA1: e602. Cloned: cosmid rescue (C46D2). [Brenner 1974; NG; SQ; WS] | |||||||||
Strain (16) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (36) | |||||||||
Structured_description | Concise_description | unc-69 encodes, by alternative splicing, three isoforms of a small (102- to 176-residue) coiled-coil protein required for normal axonal extension, axonal guidance, neuronal fasciculation, and synaptic vesicle localization; UNC-69 is orthologous to human SCOCO, which can transgenically rescue the locomotion defect of strong unc-69 mutants; UNC-69 is expressed in embryos, the processes and growth cones of immature neurons, and in the cell bodies of many (perhaps all) mature neurons; UNC-69 acts cell-autonomously in at least touch neurons, and perhaps all neurons; since UNC-69 binds a 19-residue conserved coiled-coil domain of UNC-76, UNC-69 and UNC-76 colocalize to neuronal puncta, unc-69 mutants phenotypically resemble unc-76, and mutations of these genes have nonallelic noncomplementation, UNC-69 and UNC-76 are likely to function as a complex. | Paper_evidence | WBPaper00000031 | |||||
WBPaper00001345 | |||||||||
WBPaper00002837 | |||||||||
WBPaper00027646 | |||||||||
WBPaper00027651 | |||||||||
WBPaper00031100 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 18 Oct 2007 00:00:00 | ||||||||
Automated_description | Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T07A5.6a | |||||||
T07A5.6b | |||||||||
T07A5.6c | |||||||||
Corresponding_transcript | T07A5.6a.1 | ||||||||
T07A5.6b.1 | |||||||||
T07A5.6c.1 | |||||||||
Other_sequence (59) | |||||||||
Associated_feature (12) | |||||||||
Experimental_info | RNAi_result | WBRNAi00035291 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062360 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr4900 | ||||||||
Expr7838 | |||||||||
Expr1016022 | |||||||||
Expr1032870 | |||||||||
Expr1156304 | |||||||||
Expr2017899 | |||||||||
Expr2036035 | |||||||||
Drives_construct | WBCnstr00001400 | ||||||||
WBCnstr00012320 | |||||||||
WBCnstr00012950 | |||||||||
Construct_product | WBCnstr00001400 | ||||||||
WBCnstr00012320 | |||||||||
WBCnstr00012950 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (125) | |||||||||
Interaction | WBInteraction000008990 | ||||||||
WBInteraction000522715 | |||||||||
WBInteraction000522716 | |||||||||
WBInteraction000547046 | |||||||||
Map_info | Map | III | Position | 2.3102 | Error | 0.00237 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf40 | |||||||
Positive_clone | T07A5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Negative | Outside_rearr | tnDf2 | |||||||
Mapping_data | 2_point | 72 | |||||||
578 | |||||||||
702 | |||||||||
5137 | |||||||||
6121 | |||||||||
Multi_point (75) | |||||||||
Pos_neg_data | 362 | ||||||||
669 | |||||||||
1597 | |||||||||
1620 | |||||||||
4768 | |||||||||
8638 | |||||||||
9454 | |||||||||
10533 | |||||||||
Reference (52) | |||||||||
Remark | on same cosmid as unc-50; genetic map data indicate unc-69 left of unc-50 JAH 01/01 | ||||||||
Method | Gene |