WormBase Tree Display for Gene: WBGene00006788
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WBGene00006788 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | unc-53 | Person_evidence | WBPerson261 | |||||
Sequence_name | F45E10.1 | ||||||||
Molecular_name (24) | |||||||||
Other_name | CELE_F45E10.1 | Accession_evidence | NDB | BX284602 | |||||
Public_name | unc-53 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143183 | ||||||||
Allele (424) | |||||||||
Legacy_information | e404 : sluggish poor backing dumpyish somewhat Egl; males have abnormal bursal anatomy. ES2 ME0. NA4 (n152 n166 n569). | ||||||||
See also e2432, e2499, n152, n166, n569 | |||||||||
[C.elegansII] e404 : sluggish, poor backing, dumpyish; somewhat Egl; multiple defects in neuronal outgrowth, branching; also defects in excretory canal extension, gonad arm growth; males have abnormal bursal anatomy. ES2 ME0. OA>5: n152, n166, n569 (synergizes with sem-5(n177) to give strong Sem migration defect),e2432, e2499, etc. Null phenotype uncertain; some lethality in strong alleles. Cloned: multiple transcripts (different 5' ends); one encodes 1528 aa protein, predicted to bind actin, ATP/GTP; may interact with SEM-5. Transgene overexpression leads to extension of growth cones along a-p axis. [Hedgecock et al. 1987; Hekimi and Kershaw 1993; UG] | |||||||||
Strain | WBStrain00026706 | ||||||||
WBStrain00026870 | |||||||||
WBStrain00032757 | |||||||||
WBStrain00034470 | |||||||||
WBStrain00034483 | |||||||||
WBStrain00037045 | |||||||||
WBStrain00004162 | |||||||||
WBStrain00004572 | |||||||||
WBStrain00005655 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (46) | |||||||||
Structured_description | Concise_description | unc-53 encodes at least five large (~1200-1600 residue) proteins, orthologous to human NAV1, NAV2/RAINB1 (OMIM:607026), and NAV3, and homologous to Drosophila CG10662; UNC-53 proteins are required for anteroposterior guidance of migrating cells, axons, and excretory cell canals; unc-53 mutations affect egg laying, backward locomotion, body size, and male mating; UNC-53 proteins vary in their N-terminal regions but share common C-terminal sequences with a AAA-ATPase domain; the UNC-53 N-terminus physically interacts with ABI-1, suggesting that UNC-53 may function as a scaffold to link the ARP2/3 complex to ABI-1; UNC-53 also interacts both physically and genetically with SEM-5; unc-53 is expressed in those cells requiring it, suggesting that its function is cell-autonomous; overexpression of unc-53 induces excess cellular outgrowth. | Paper_evidence (11) | ||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 13 Nov 2012 00:00:00 | ||||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including backward locomotion; positive regulation of locomotion; and reproductive behavior. Located in cytoplasm. Expressed in several structures, including excretory cell; hermaphrodite distal tip cell; neurons; non-striated muscle; and socket cell. Human ortholog(s) of this gene implicated in opiate dependence. Is an ortholog of human NAV1 (neuron navigator 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2559 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15998) | ||||
Molecular_info | Corresponding_CDS (8) | ||||||||
Corresponding_CDS_history | F45E10.1:wp82 | ||||||||
Corresponding_transcript | F45E10.1a.1 | ||||||||
F45E10.1b.1 | |||||||||
F45E10.1c.1 | |||||||||
F45E10.1d.1 | |||||||||
F45E10.1e.1 | |||||||||
F45E10.1f.1 | |||||||||
F45E10.1g.1 | |||||||||
F45E10.1h.1 | |||||||||
Other_sequence (27) | |||||||||
Associated_feature (66) | |||||||||
Experimental_info | RNAi_result (14) | ||||||||
Expr_pattern (12) | |||||||||
Drives_construct (25) | |||||||||
Construct_product | WBCnstr00009444 | ||||||||
WBCnstr00010519 | |||||||||
WBCnstr00010520 | |||||||||
WBCnstr00010521 | |||||||||
WBCnstr00034150 | |||||||||
Antibody | WBAntibody00001615 | ||||||||
WBAntibody00001625 | |||||||||
Microarray_results (40) | |||||||||
Expression_cluster (222) | |||||||||
Interaction (103) | |||||||||
Anatomy_function | WBbtf0113 | ||||||||
WBbtf0114 | |||||||||
WBbtf0118 | |||||||||
WBbtf0119 | |||||||||
Map_info | Map | II | Position | 3.16568 | Error | 0.005694 | |||
Well_ordered | |||||||||
Positive | Positive_clone | F45E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
T28D2 | |||||||||
Mapping_data | 2_point | 43 | |||||||
Multi_point (11) | |||||||||
Pos_neg_data | 2145 | ||||||||
2146 | |||||||||
2159 | |||||||||
2163 | |||||||||
4533 | |||||||||
4534 | |||||||||
4535 | |||||||||
4536 | |||||||||
4539 | |||||||||
10562 | |||||||||
Reference (100) | |||||||||
Method | Gene |