WormBase Tree Display for Gene: WBGene00006775
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WBGene00006775 | SMap | S_parent | Sequence | F56A12 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | unc-39 | Person_evidence | WBPerson261 | |||||
Sequence_name | F56A12.1 | ||||||||
Molecular_name | F56A12.1 | ||||||||
F56A12.1.1 | |||||||||
CE37921 | |||||||||
Other_name | mig-3 | ||||||||
ceh-35 | Paper_evidence | WBPaper00024327 | |||||||
CELE_F56A12.1 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | unc-39 | ||||||||
DB_info | Database | AceView | gene | 5O855 | |||||
WormQTL | gene | WBGene00006775 | |||||||
WormFlux | gene | WBGene00006775 | |||||||
OMIM | disease | 610896 | |||||||
160900 | |||||||||
gene | 600963 | ||||||||
NDB | locus_tag | CELE_F56A12.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006775|UniProtKB=O17894 | |||||||
family | PTHR10390 | ||||||||
NCBI | gene | 191623 | |||||||
RefSeq | protein | NM_074162.3 | |||||||
SwissProt | UniProtAcc | O17894 | |||||||
UniProt_GCRP | UniProtAcc | O17894 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 09 Nov 2004 14:53:34 | WBPerson2970 | Event | Acquires_merge | WBGene00000456 | ||||
Acquires_merge | WBGene00000456 | ||||||||
Status | Live | ||||||||
Gene_info (11) | |||||||||
Disease_info | Experimental_model | DOID:11722 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||||
Accession_evidence | OMIM | 160900 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
DOID:14702 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||||||
Accession_evidence | OMIM | 610896 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
Potential_model | DOID:0111424 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10891) | |||||
Disease_relevance | Mutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy. | Homo sapiens | Paper_evidence | WBPaper00024327 | |||||
Accession_evidence | OMIM | 600963 | |||||||
160900 | |||||||||
610896 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 01 May 2014 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000238 | ||||||||
WBDOannot00000299 | |||||||||
Molecular_info (7) | |||||||||
Experimental_info | RNAi_result | WBRNAi00101784 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00032912 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089718 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090158 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00090317 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061182 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00015762 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00048581 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00114716 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00089999 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00004349 | ||||||||
WBCnstr00011130 | |||||||||
WBCnstr00012730 | |||||||||
WBCnstr00015880 | |||||||||
WBCnstr00016522 | |||||||||
WBCnstr00034159 | |||||||||
Construct_product | WBCnstr00011130 | ||||||||
WBCnstr00015880 | |||||||||
WBCnstr00016701 | |||||||||
WBCnstr00034159 | |||||||||
Regulate_expr_cluster | WBPaper00050496:unc-39(hp701)_regulated | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (153) | |||||||||
Interaction (134) | |||||||||
Map_info | Map | V | Position | 6.28117 | Error | 0.001023 | |||
Positive | Positive_clone | F56A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 132 | |||||||
839 | |||||||||
1725 | |||||||||
Multi_point (14) | |||||||||
Pos_neg_data | 297 | ||||||||
2131 | |||||||||
3132 | |||||||||
4308 | |||||||||
Reference (35) | |||||||||
Method | Gene |