WormBase Tree Display for Gene: WBGene00006369
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WBGene00006369 | SMap | S_parent | Sequence | R03E1 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | sym-4 | Person_evidence | WBPerson252 | |||||
Sequence_name | R03E1.1 | ||||||||
Molecular_name | R03E1.1 | ||||||||
R03E1.1.1 | |||||||||
CE18901 | |||||||||
Other_name | CELE_R03E1.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sym-4 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sym | ||||||||
Allele (116) | |||||||||
Legacy_information | [Herman RK] sym-4(mn619) or sym-4(mn620) by itself is essentially wild type but is synthetic lethal with any mec-8 loss-of-function mutation | ||||||||
Strain | WBStrain00003499 | ||||||||
WBStrain00034406 | |||||||||
RNASeq_FPKM (74) | |||||||||
Contained_in_operon | CEOPX128 | ||||||||
Ortholog (37) | |||||||||
Structured_description | Concise_description | sym-4 encodes a large (1,043-residue) protein that is required for viability in a mec-8 mutant background, and is also required by itself for normally rapid growth and locomotion; SYM-4 is orthologous to human WDR44, and has a nondescript N-terminal domain, with a C-terminal domain containing seven WD repeats; SYM-4 is broadly expressed, in larval and adult pharynx, digestive tract, neurons, vulva, body wall muscle, and coelomocytes; sym-4 is synthetically lethal with mec-8, with double mutants showing an abnormally buccal cavity between the anterior end of the embryo and the internal anterior end of the pharyngeal primordium; mec-8;sym-4 embryos arrest development at hatching, are unable to eat, and thus die; SYM-4 may function in concert with SYM-3, since sym-3 mutants have the same synthetic lethal phenotype as sym-4. | Paper_evidence | WBPaper00003663 | |||||
WBPaper00006395 | |||||||||
WBPaper00006525 | |||||||||
WBPaper00024639 | |||||||||
WBPaper00031006 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 03 Jan 2008 00:00:00 | ||||||||
Automated_description | Enriched in several structures, including ABalapapap; excretory cell; head mesodermal cell; neurons; and oocyte based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including nuo-6; hsf-1; and mrg-1 based on microarray; tiling array; and RNA-seq studies. Is affected by four chemicals including rotenone; stavudine; and fluvastatin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: WD40/YVTN repeat-like-containing domain superfamily; WD40 repeat; WD40-repeat-containing domain superfamily; WD repeat-containing protein WDR44/Dgr2; Phosphorylation site; and WD domain, G-beta repeat. Is an ortholog of human WDR44 (WD repeat domain 44). Human WDR44 enables molecular sequestering activity and small GTPase binding activity. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | R03E1.1 | |||||||
Corresponding_transcript | R03E1.1.1 | ||||||||
Other_sequence (31) | |||||||||
Associated_feature | WBsf654560 | ||||||||
WBsf671239 | |||||||||
WBsf982278 | |||||||||
WBsf1007841 | |||||||||
WBsf1007842 | |||||||||
WBsf238203 | |||||||||
WBsf238204 | |||||||||
Experimental_info | RNAi_result | WBRNAi00062558 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00000324 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00017353 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00026014 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00034557 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00051178 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00027424 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00062557 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Chronogram453 | ||||||||
Expr6450 | |||||||||
Expr1025719 | |||||||||
Expr1032568 | |||||||||
Expr1154885 | |||||||||
Expr2017182 | |||||||||
Expr2035318 | |||||||||
Drives_construct | WBCnstr00003957 | ||||||||
WBCnstr00034385 | |||||||||
Construct_product | WBCnstr00034385 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (98) | |||||||||
Interaction (27) | |||||||||
Map_info | Map | X | Position | 16.6582 | Error | 0.012267 | |||
Positive | Inside_rearr | mnDp1 | |||||||
Positive_clone | R03E1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Negative | Outside_rearr | mnDf19 | |||||||
Mapping_data | 2_point | 7094 | |||||||
7095 | |||||||||
Multi_point | 4152 | ||||||||
Pos_neg_data | 10233 | ||||||||
10234 | |||||||||
Reference (14) | |||||||||
Method | Gene |