WormBase Tree Display for Gene: WBGene00006365
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| WBGene00006365 | Evidence | Paper_evidence | WBPaper00005760 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K02E10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | syg-1 | Person_evidence | WBPerson42 | |||||
| Sequence_name | K02E10.8 | ||||||||
| Molecular_name | K02E10.8a | ||||||||
| K02E10.8a.1 | |||||||||
| CE37121 | |||||||||
| K02E10.8b | |||||||||
| CE42267 | |||||||||
| K02E10.8c | |||||||||
| CE33930 | |||||||||
| K02E10.8b.1 | |||||||||
| K02E10.8c.1 | |||||||||
| Other_name | CELE_K02E10.8 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | syg-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | syg | ||||||||
| Allele (94) | |||||||||
| Strain | WBStrain00033289 | ||||||||
| WBStrain00005219 | |||||||||
| WBStrain00037920 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00004729 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00007750 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018215 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020130 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | syg-1 encodes a novel transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-1 activity is required cell autonomously within the HSNL neuron to specify proper synaptic specificity with its targets, such as vulval muscles and the VC neuron; in regulating synapse formation, SYG-1 acts as a receptor for a second immunoglobulin superfamily protein, SYG-2, a synaptic guidepost protein that interacts with SYG-1 and whose activity is essential for proper SYG-1 localization in HSNL; expression of a SYG-1::GFP reporter fusion in HSNL under the control of the unc-86 promoter reveals that SYG-1 localizes to axons and accumulates at future sites of synaptic vesicle clustering, while expression under an endogenous reporter reveals weak expression in head motorneurons, occasionally in HSN neurons, and in other cells in the vulval region. | Paper_evidence | WBPaper00005760 | |||||
| WBPaper00006489 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 21 Mar 2006 00:00:00 | ||||||||
| Automated_description | Enables cell adhesion molecule binding activity. Involved in actin filament bundle assembly; cell-cell signaling; and nervous system development. Located in axon and synapse. Expressed in amphid sheath cell; egg-laying apparatus; head muscle; hypodermis; and neurons. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 23. Is an ortholog of human KIRREL1 (kirre like nephrin family adhesion molecule 1) and KIRREL2 (kirre like nephrin family adhesion molecule 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed (2) | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1184 | Homo sapiens | Paper_evidence | WBPaper00036034 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 02 Jul 2018 00:00:00 | ||||||||
| Potential_model | DOID:0112266 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15734) | |||||
| Models_disease_asserted | WBDOannot00000574 | ||||||||
| Molecular_info | Corresponding_CDS | K02E10.8a | |||||||
| K02E10.8b | |||||||||
| K02E10.8c | |||||||||
| Corresponding_CDS_history | K02E10.8:wp99 | ||||||||
| K02E10.8:wp128 | |||||||||
| K02E10.8:wp188 | |||||||||
| Corresponding_transcript | K02E10.8a.1 | ||||||||
| K02E10.8b.1 | |||||||||
| K02E10.8c.1 | |||||||||
| Other_sequence | CBC11339_1 | ||||||||
| JI166835.1 | |||||||||
| Dviv_isotig31560 | |||||||||
| Acan_isotig12092 | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00049710 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00016458 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007263 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (13) | |||||||||
| Construct_product | WBCnstr00000856 | ||||||||
| WBCnstr00007271 | |||||||||
| WBCnstr00007273 | |||||||||
| WBCnstr00007274 | |||||||||
| WBCnstr00011386 | |||||||||
| WBCnstr00034389 | |||||||||
| WBCnstr00038451 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (37) | |||||||||
| Anatomy_function | WBbtf0202 | ||||||||
| WBbtf0203 | |||||||||
| WBbtf0204 | |||||||||
| WBbtf0205 | |||||||||
| WBbtf0206 | |||||||||
| Map_info | Map | X | Position | -14.7236 | Error | 0.103894 | |||
| Positive | Positive_clone | K02E10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4716 | |||||||
| 4787 | |||||||||
| 5615 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (43) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
