WormBase Tree Display for Gene: WBGene00004353

WBGene00004353 SMap: S_parent: Sequence: F45B8
  Identity: Version: 2
    Name: CGC_name: rgs-10 Person_evidence: WBPerson330
      Sequence_name: F45B8.2
      Molecular_name: F45B8.2
        F45B8.2.1
        CE10430
      Other_name: tag-215 Curator_confirmed: WBPerson2970
        CELE_F45B8.2 Accession_evidence: NDB BX284606
      Public_name: rgs-10
    DB_info: Database: AceView gene XP581
        WormQTL gene WBGene00004353
        WormFlux gene WBGene00004353
        NDB locus_tag CELE_F45B8.2
        Panther gene CAEEL|WormBase=WBGene00004353|UniProtKB=O45523
          family PTHR10845
        NCBI gene 185764
        RefSeq protein NM_078081.2
        SwissProt UniProtAcc O45523
        UniProt_GCRP UniProtAcc O45523
        OMIM gene 603276
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 03 Dec 2004 16:57:36 WBPerson2970 Event: Acquires_merge: WBGene00009719
      Acquires_merge: WBGene00009719
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rgs
    Allele (38)
    Strain: WBStrain00026378
      WBStrain00031781
      WBStrain00035991
    RNASeq_FPKM (74)
    GO_annotation: 00036229
    Ortholog (46)
    Paralog: WBGene00004344 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00004345 Caenorhabditis elegans From_analysis: Panther
      WBGene00004346 Caenorhabditis elegans From_analysis: Panther
      WBGene00004347 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00004350 Caenorhabditis elegans From_analysis: TreeFam
            Panther
      WBGene00004351 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00004352 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00021988 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00004354 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to be involved in negative regulation of signal transduction. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Is an ortholog of several human genes including RGS1 (regulator of G protein signaling 1); RGS2 (regulator of G protein signaling 2); and RGS4 (regulator of G protein signaling 4). Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Disease_info: Potential_model: DOID:0050741 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10000)
      DOID:10825 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10001)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10001)
  Molecular_info: Corresponding_CDS: F45B8.2
    Corresponding_transcript: F45B8.2.1
    Associated_feature: WBsf1008050
  Experimental_info: RNAi_result: WBRNAi00047346 Inferred_automatically: RNAi_primary
      WBRNAi00061483 Inferred_automatically: RNAi_primary
      WBRNAi00014974 Inferred_automatically: RNAi_primary
      WBRNAi00032272 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1027844
      Expr1032170
      Expr1151199
      Expr2015322
      Expr2033556
    Drives_construct: WBCnstr00035544
    Construct_product: WBCnstr00035544
    Microarray_results (15)
    Expression_cluster (134)
    Interaction (50)
  Map_info: Map: X Position: 21.5995 Error: 0.003428
    Positive: Positive_clone: F45B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5033
        5052
    Pseudo_map_position
  Reference: WBPaper00004281
    WBPaper00066805
    WBPaper00067477
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene