WormBase Tree Display for Gene: WBGene00003566
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| WBGene00003566 | Evidence | Author_evidence | Schwartz EM | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y113G7A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ncx-1 | |||||||
| Sequence_name | Y113G7A.4 | ||||||||
| Molecular_name | Y113G7A.4a | ||||||||
| Y113G7A.4a.1 | |||||||||
| CE23275 | |||||||||
| Y113G7A.4b | |||||||||
| CE40149 | |||||||||
| Y113G7A.4b.1 | |||||||||
| Other_name | CELE_Y113G7A.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | ncx-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00003566 | |||||
| WormFlux | gene | WBGene00003566 | |||||||
| NDB | locus_tag | CELE_Y113G7A.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003566|UniProtKB=G5EF08 | |||||||
| family | PTHR11878 | ||||||||
| NCBI | gene | 180318 | |||||||
| RefSeq | protein | NM_001047718.6 | |||||||
| NM_001047717.7 | |||||||||
| TREEFAM | TREEFAM_ID | TF314308 | |||||||
| TrEMBL | UniProtAcc | G5EF08 | |||||||
| Q1RPT9 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EF08 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ncx | ||||||||
| Allele (438) | |||||||||
| Legacy_information | [Kraev A] ncx for Na/Ca eXchanger. No mutants known. Named for similarity to sodium-calcium(potassium) exchangers, isolated from various species from squid to mammals. Typical features include a similar predicted transmembrane architecture, namely 5 transmembrane domains -cytoplasmic loop -6 transmembrane domains, TM domains 2/3 and 8/9 are show internal similarity and are called "alpha-repeats", believed to be involved in the ion transport mechanism. Overall similarity to squid neuronal Na/Ca exchanger (ncx-1 to -3) and to mammalian brain Na/Ca,K-exchangers NCKX-2 and NCKX-3 (ncx-4 and ncx-5) | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (54) | |||||||||
| Paralog | WBGene00003567 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003568 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | ncx-1 encodes, by alternative splicing, two isoforms of a putative 3Na[+]/1Ca[2+] exchanger, orthologous to human SLC8A1-3 and paralogous to NCX-2/-3; NCX-1 is predicted to export free cytoplasmic Ca[2+] with low affinity but high capacity, being complemented by low-capacity/high-affinity Ca[2+] ATPase pumps such as MCA-1/-3; NCX-3 has tandem Calx-alpha and Calx-beta domains predicted to carry out ion transport and regulation; NCX-1 is required for embryonic viability in mass RNAi assays. | Paper_evidence | WBPaper00012774 | |||||
| WBPaper00025054 | |||||||||
| WBPaper00028596 | |||||||||
| WBPaper00031156 | |||||||||
| WBPaper00031157 | |||||||||
| WBPaper00031158 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 07 Nov 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium:sodium antiporter activity. Predicted to be involved in calcium ion import across plasma membrane and sodium ion transmembrane transport. Predicted to be located in axon; postsynapse; and sarcolemma. Expressed in AIYL and AIYR. Human ortholog(s) of this gene implicated in Alzheimer's disease and pulmonary hypertension. Is an ortholog of human SLC8A1 (solute carrier family 8 member A1) and SLC8A2 (solute carrier family 8 member A2). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11068,HGNC:11069,HGNC:11070) | ||||
| DOID:6432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11068) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11068) | ||||||
| Molecular_info | Corresponding_CDS | Y113G7A.4a | |||||||
| Y113G7A.4b | |||||||||
| Corresponding_transcript | Y113G7A.4a.1 | ||||||||
| Y113G7A.4b.1 | |||||||||
| Other_sequence (77) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00055385 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00030264 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11155 | ||||||||
| Expr1014144 | |||||||||
| Expr1031624 | |||||||||
| Expr1158902 | |||||||||
| Expr2013918 | |||||||||
| Expr2032158 | |||||||||
| Drives_construct | WBCnstr00018015 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (176) | |||||||||
| Interaction (22) | |||||||||
| Map_info | Map | V | Position | 24.7655 | Error | 0.020557 | |||
| Positive | Positive_clone | Y102G3 | |||||||
| Y113G7A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00011772 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00062223 | |||||||||
| WBPaper00064902 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
