WormBase Tree Display for Gene: WBGene00003519
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| WBGene00003519 | Evidence | Paper_evidence | WBPaper00005726 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K08E5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | nac-3 | |||||||
| Sequence_name | K08E5.2 | ||||||||
| Molecular_name | K08E5.2a | ||||||||
| K08E5.2a.1 | |||||||||
| CE33531 | |||||||||
| K08E5.2b | |||||||||
| CE33532 | |||||||||
| K08E5.2b.1 | |||||||||
| K08E5.2b.2 | |||||||||
| Other_name | indy-2 | Accession_evidence | EMBL | AY090485 | |||||
| nad-2 | |||||||||
| cenadc2 | |||||||||
| CELE_K08E5.2 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | nac-3 | ||||||||
| DB_info | Database | AceView | gene | 3L247 | |||||
| WormQTL | gene | WBGene00003519 | |||||||
| WormFlux | gene | WBGene00003519 | |||||||
| NDB | locus_tag | CELE_K08E5.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003519|UniProtKB=Q21339 | |||||||
| family | PTHR10283 | ||||||||
| NCBI | gene | 176429 | |||||||
| RefSeq | protein | NM_001392186.1 | |||||||
| NM_001027502.5 | |||||||||
| SwissProt | UniProtAcc | Q21339 | |||||||
| UniProt_GCRP | UniProtAcc | Q21339 | |||||||
| OMIM | gene | 608305 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nac | ||||||||
| Allele (82) | |||||||||
| Strain | WBStrain00032461 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00003517 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003518 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00007138 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | nac-3 encodes a high affinity, sodium-coupled dicarboxylate transporter that is one of four C. elegans proteins related to Drosophila Indy and the mammalian NaDC1 and NaDC3 transporters; when expressed in a heterologous system, NAC-3 exhibits high affinity sodium/succinate cotransporter activity indicating that, functionally, NAC-3 is more closely related to mammalian NaDC3 than NaDC1; nac-3 mRNA is present during larval and adult stages, with highest levels seen in L3 and L4 larvae; nac-3::gfp reporter fusions are expressed in the intestine, from early larval stages through adulthood; the effects of nac-3(RNAi) on average lifespan are variable, with reports of no effect on lifespan and reports of a 15% increase in lifespan in affected animals. | Paper_evidence | WBPaper00005726 | |||||
| WBPaper00006504 | |||||||||
| WBPaper00030797 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 19 Jun 2007 00:00:00 | ||||||||
| Automated_description | Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in determination of adult lifespan and succinate transport. Predicted to be located in plasma membrane. Expressed in alimentary system. Is an ortholog of human SLC13A2 (solute carrier family 13 member 2). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080453 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23089) | ||||
| Molecular_info | Corresponding_CDS | K08E5.2a | |||||||
| K08E5.2b | |||||||||
| Corresponding_CDS_history | K08E5.2:wp57 | ||||||||
| K08E5.2:wp96 | |||||||||
| Corresponding_transcript | K08E5.2a.1 | ||||||||
| K08E5.2b.1 | |||||||||
| K08E5.2b.2 | |||||||||
| Other_sequence (25) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00006967 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00050298 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022869 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00000818 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00050299 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034141 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066315 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00016812 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2368 | ||||||||
| Expr1012849 | |||||||||
| Expr1031613 | |||||||||
| Expr1154000 | |||||||||
| Expr2013854 | |||||||||
| Expr2032094 | |||||||||
| Drives_construct | WBCnstr00000314 | ||||||||
| WBCnstr00036075 | |||||||||
| Construct_product | WBCnstr00036075 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (180) | |||||||||
| Interaction (120) | |||||||||
| Map_info | Map | III | Position | 1.94699 | Error | 0.011675 | |||
| Positive | Positive_clone | K08E5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005726 | ||||||||
| WBPaper00006504 | |||||||||
| WBPaper00025195 | |||||||||
| WBPaper00030797 | |||||||||
| WBPaper00035539 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
