WormBase Tree Display for Gene: WBGene00003239
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WBGene00003239 | SMap | S_parent | Sequence | C35C5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | mig-2 | Person_evidence | WBPerson261 | |||||
Sequence_name | C35C5.4 | ||||||||
Molecular_name | C35C5.4a | ||||||||
C35C5.4a.1 | |||||||||
CE18544 | |||||||||
C35C5.4b | |||||||||
CE50721 | |||||||||
C35C5.4b.1 | |||||||||
Other_name | CELE_C35C5.4 | Accession_evidence | NDB | BX284606 | |||||
Public_name | mig-2 | ||||||||
DB_info | Database | AceView | gene | XM167 | |||||
WormQTL | gene | WBGene00003239 | |||||||
WormFlux | gene | WBGene00003239 | |||||||
NDB | locus_tag | CELE_C35C5.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3 | |||||||
family | PTHR24072 | ||||||||
NCBI | gene | 181344 | |||||||
RefSeq | protein | NM_077530.5 | |||||||
NM_001313405.4 | |||||||||
TrEMBL | UniProtAcc | A0A0K3AYI6 | |||||||
G5EBV3 | |||||||||
UniProt_GCRP | UniProtAcc | G5EBV3 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mig | ||||||||
Allele (39) | |||||||||
Legacy_information | rh17 : variable abnormal migration of Q neuroblasts HSN cells CAN cells. | ||||||||
[C.elegansII] rh17 : variable abnormal migration of Q neuroblasts, HSN cells, CAN cells etc.; Egl; uncoordinated; axon defects. OA1. [Hedgecock et al. 1987; Desai et al. 1988; NJ] | |||||||||
[Zipkin ID, Kindt RM, Kenyon CJ] mu28 homozygotes exhibit abnormal migration of Q daughters. Predicted gene C35C5.4, encodes Rho-related protein. | |||||||||
Strain | WBStrain00024138 | ||||||||
WBStrain00024141 | |||||||||
WBStrain00024146 | |||||||||
WBStrain00024159 | |||||||||
WBStrain00024170 | |||||||||
WBStrain00024172 | |||||||||
WBStrain00028737 | |||||||||
WBStrain00028748 | |||||||||
WBStrain00032460 | |||||||||
WBStrain00004808 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (52) | |||||||||
Ortholog (39) | |||||||||
Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004287 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | mig-2 encodes a member of the RhoG family of GTP-binding proteins; MIG-2 activity is required for migration of Q neuroblasts, HSN neurons, and CAN cells as well as neurite outgrowth and guidance; in regulating Q neuroblast migration and dendrite outgrowth, MIG-2 functions upstream of the ANI-1 anillin to asymmetrically regulate ANI-1 localization, and thus stabilize F-actin, at the leading edge and growth cone; MIG-2 is expressed in early embryos and in adults in the vulva, gonadal distal tip cells, and the sex myoblasts and their descendants. | Paper_evidence | WBPaper00046615 | |||||
WBPaper00002878 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson48 | |||||||||
WBPerson1843 | |||||||||
Date_last_updated | 28 May 2015 00:00:00 | ||||||||
Automated_description | Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 | ||||
Curator_confirmed | WBPerson38202 | ||||||||
Date_last_updated | 04 Jun 2018 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000557 | ||||||||
Molecular_info | Corresponding_CDS | C35C5.4a | |||||||
C35C5.4b | |||||||||
Corresponding_transcript | C35C5.4a.1 | ||||||||
C35C5.4b.1 | |||||||||
Other_sequence (25) | |||||||||
Associated_feature | WBsf663364 | ||||||||
WBsf1007033 | |||||||||
WBsf1007034 | |||||||||
WBsf1007035 | |||||||||
WBsf236390 | |||||||||
WBsf236391 | |||||||||
WBsf236392 | |||||||||
WBsf236393 | |||||||||
WBsf236394 | |||||||||
Experimental_info | RNAi_result (20) | ||||||||
Expr_pattern | Expr1463 | ||||||||
Expr8941 | |||||||||
Expr12554 | |||||||||
Expr16070 | |||||||||
Expr1019676 | |||||||||
Expr1031535 | |||||||||
Expr1145980 | |||||||||
Expr2013570 | |||||||||
Expr2031803 | |||||||||
Drives_construct | WBCnstr00000269 | ||||||||
WBCnstr00001031 | |||||||||
WBCnstr00001032 | |||||||||
WBCnstr00036166 | |||||||||
Construct_product | WBCnstr00001031 | ||||||||
WBCnstr00007681 | |||||||||
WBCnstr00007697 | |||||||||
WBCnstr00009004 | |||||||||
WBCnstr00017999 | |||||||||
WBCnstr00036166 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (122) | |||||||||
Interaction (285) | |||||||||
WBProcess | WBbiopr:00000006 | ||||||||
WBbiopr:00000015 | |||||||||
WBbiopr:00000107 | |||||||||
WBbiopr:00000111 | |||||||||
Map_info | Map | X | Position | 4.35742 | Error | 0.06415 | |||
Well_ordered | |||||||||
Positive | Positive_clone | C35C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 3673 | |||||||
Reference (180) | |||||||||
Remark | Data extracted from Zipkin et al. (1997) | ||||||||
Method | Gene |