WormBase Tree Display for Gene: WBGene00001851
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WBGene00001851 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | hif-1 | Person_evidence | WBPerson496 | |||||
Sequence_name | F38A6.3 | ||||||||
Molecular_name (18) | |||||||||
Other_name | CELE_F38A6.3 | Accession_evidence | NDB | BX284605 | |||||
Public_name | hif-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hif | ||||||||
Allele (81) | |||||||||
Strain (23) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (34) | |||||||||
Ortholog (50) | |||||||||
Paralog | WBGene00000521 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00011327 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | hif-1 encodes an ortholog of the mammalian hypoxia-induced factor HIF-1, and is required for survival in hypoxic environments (1% oxygen) that have no effect on wild-type C. elegans. | Paper_evidence | WBPaper00004762 | |||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and response to stress. Located in nucleus. Expressed widely. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); familial erythrocytosis 4; and hypertension (multiple). Is an ortholog of human EPAS1 (endothelial PAS domain protein 1) and HIF3A (hypoxia inducible factor 3 subunit alpha). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00036343 | ||||
Curator_confirmed | WBPerson38202 | ||||||||
Date_last_updated | 02 Jul 2018 00:00:00 | ||||||||
Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | |||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:8893 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:8432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:8398 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:6432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:14175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
DOID:0080339 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3374) | ||||||
Models_disease_asserted | WBDOannot00000595 | ||||||||
Molecular_info | Corresponding_CDS | F38A6.3a | |||||||
F38A6.3b | |||||||||
F38A6.3c | |||||||||
F38A6.3d | |||||||||
F38A6.3e | |||||||||
F38A6.3f | |||||||||
Corresponding_CDS_history | F38A6.3a:wp188 | ||||||||
F38A6.3b:wp188 | |||||||||
F38A6.3d:wp140 | |||||||||
F38A6.3e:wp188 | |||||||||
Corresponding_transcript | F38A6.3a.1 | ||||||||
F38A6.3b.1 | |||||||||
F38A6.3c.1 | |||||||||
F38A6.3d.1 | |||||||||
F38A6.3e.1 | |||||||||
F38A6.3f.1 | |||||||||
Other_sequence (34) | |||||||||
Associated_feature | WBsf647762 | ||||||||
WBsf647763 | |||||||||
WBsf661080 | |||||||||
WBsf982096 | |||||||||
WBsf1003642 | |||||||||
WBsf1003643 | |||||||||
WBsf1003644 | |||||||||
WBsf1003645 | |||||||||
WBsf1022012 | |||||||||
WBsf1022013 | |||||||||
Gene_product_binds | WBsf919675 | ||||||||
WBsf919676 | |||||||||
WBsf919677 | |||||||||
WBsf919681 | |||||||||
WBsf919682 | |||||||||
WBsf919683 | |||||||||
Transcription_factor | WBTranscriptionFactor000728 | ||||||||
Experimental_info | RNAi_result (53) | ||||||||
Expr_pattern | Expr1246 | ||||||||
Expr1020261 | |||||||||
Expr1031087 | |||||||||
Expr1150556 | |||||||||
Expr2012413 | |||||||||
Expr2030649 | |||||||||
Drives_construct (12) | |||||||||
Construct_product (28) | |||||||||
Regulate_expr_cluster | WBPaper00055941:hif-1(ia4)_downregulated | ||||||||
WBPaper00055941:hif-1(ia4)_upregulated | |||||||||
Antibody | WBAntibody00000413 | ||||||||
WBAntibody00002054 | |||||||||
WBAntibody00002195 | |||||||||
Microarray_results (45) | |||||||||
Expression_cluster (150) | |||||||||
Interaction (145) | |||||||||
WBProcess | WBbiopr:00000008 | ||||||||
WBbiopr:00000054 | |||||||||
WBbiopr:00000096 | |||||||||
Map_info | Map | V | Position | 25.1977 | Error | 0.022563 | |||
Positive | Positive_clone | F38A6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4283 | |||||||
4401 | |||||||||
4651 | |||||||||
Pseudo_map_position | |||||||||
Reference (221) | |||||||||
Remark | Sequence connection from [Powell-Coffman JA] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |