WormBase Tree Display for Gene: WBGene00001526
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| WBGene00001526 | SMap | S_parent | Sequence | T19A5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gck-1 | Person_evidence | WBPerson565 | |||||
| Sequence_name | T19A5.2 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_T19A5.2 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | gck-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gck | ||||||||
| Allele (115) | |||||||||
| Strain | WBStrain00022765 | ||||||||
| WBStrain00035558 | |||||||||
| WBStrain00034752 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Contained_in_operon | CEOP5569 | ||||||||
| Ortholog (41) | |||||||||
| Paralog (27) | |||||||||
| Structured_description | Concise_description | gck-1 encodes one of eight C. elegans germinal center kinases (GCKs) that are members of the Ste20-related family of kinases; GCK-1 is the sole C. elegans GCK-III subfamily member; during reproductive development, GCK-1 functions in the germ line to regulate oocyte development by inhibiting activation of a specific MPK-1 isoform, MPK-1a, and by negatively regulating physiological germline apoptosis; GCK-1 physically interacts with MPK-1a in vitro suggesting that, in vivo, GCK-1 inhibits MPK-1a by a direct interaction. | Paper_evidence | WBPaper00035301 | |||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 15 Oct 2009 00:00:00 | ||||||||
| Automated_description | Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of oocyte development. Located in cytoplasm and cytoplasmic side of apical plasma membrane. Used to study cerebral cavernous malformation. Is an ortholog of human STK26 (serine/threonine kinase 26). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:0060669 | Homo sapiens | Paper_evidence | WBPaper00046519 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Sep 2020 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000810 | ||||||||
| Molecular_info | Corresponding_CDS | T19A5.2a | |||||||
| T19A5.2b | |||||||||
| T19A5.2c | |||||||||
| T19A5.2d | |||||||||
| T19A5.2e | |||||||||
| T19A5.2f | |||||||||
| T19A5.2g | |||||||||
| T19A5.2h | |||||||||
| Corresponding_CDS_history | T19A5.2b:wp239 | ||||||||
| T19A5.2c:wp239 | |||||||||
| Corresponding_transcript | T19A5.2a.1 | ||||||||
| T19A5.2b.1 | |||||||||
| T19A5.2c.1 | |||||||||
| T19A5.2d.1 | |||||||||
| T19A5.2e.1 | |||||||||
| T19A5.2f.1 | |||||||||
| T19A5.2g.1 | |||||||||
| T19A5.2h.1 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (20) | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr1011654 | ||||||||
| Expr1030918 | |||||||||
| Expr1157045 | |||||||||
| Expr1200202 | |||||||||
| Expr2011962 | |||||||||
| Expr2030199 | |||||||||
| Drives_construct | WBCnstr00036888 | ||||||||
| Construct_product | WBCnstr00036888 | ||||||||
| Microarray_results (49) | |||||||||
| Expression_cluster (103) | |||||||||
| Interaction (71) | |||||||||
| Map_info | Map | V | Position | 1.87047 | Error | 0.002963 | |||
| Positive | Positive_clone | T19A5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4336 | |||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Sequence connection from [Schumacher JM] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
