WormBase Tree Display for Gene: WBGene00001400
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WBGene00001400 | SMap | S_parent | Sequence | F56E3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | fax-1 | Person_evidence | WBPerson691 | |||||
Sequence_name | F56E3.4 | ||||||||
Molecular_name | F56E3.4a | ||||||||
F56E3.4a.1 | |||||||||
CE28464 | |||||||||
F56E3.4b | |||||||||
CE04670 | |||||||||
F56E3.4b.1 | |||||||||
Other_name | nhr-29 | ||||||||
CELE_F56E3.4 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | fax-1 | ||||||||
DB_info | Database | AceView | gene | XD816 | |||||
WormQTL | gene | WBGene00001400 | |||||||
WormFlux | gene | WBGene00001400 | |||||||
NDB | locus_tag | CELE_F56E3.4 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00001400|UniProtKB=G5EDJ0 | |||||||
family | PTHR24083 | ||||||||
NCBI | gene | 180609 | |||||||
RefSeq | protein | NM_001277024.2 | |||||||
NM_076146.4 | |||||||||
SwissProt | UniProtAcc | G5EDJ0 | |||||||
UniProt_GCRP | UniProtAcc | G5EDJ0 | |||||||
OMIM | gene | 604485 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | fax | ||||||||
Allele (57) | |||||||||
Legacy_information | [Wightman B] Mutations cause a weak kinker phenotype and defects in axon guidance of HSNL, AVKR, PVQL axons. | ||||||||
[Wightman B] encoded by F56E3.4 nuclear hormone receptor, mutants are Unc, egg-laying constitutive, and have defects in axon pathfinding in the ventral nerve cord. | |||||||||
Strain | WBStrain00027632 | ||||||||
WBStrain00001394 | |||||||||
WBStrain00027630 | |||||||||
WBStrain00028736 | |||||||||
WBStrain00028744 | |||||||||
WBStrain00031525 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog (34) | |||||||||
Paralog (43) | |||||||||
Structured_description | Concise_description | fax-1 encodes a conserved nuclear receptor that contains two C4-type zinc fingers and is orthologous to the vertebrate photoreceptor-specific nuclear receptor PNR (OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); fax-1 is required for normal locomotion and neuron fate specification, including specification of the AVA, AVE, and AVK interneurons and proper axon pathfinding of the AVK, HSNL, and PVQL axons; expression of reporter gene fusions in fax-1 mutants suggests that fax-1 functions by regulating expression of a number of downstream targets, including nmr-1 and nmr-2, opt-3, flp-1, and ncs-1; in some neurons, fax-1 regulates expression combinatorially with unc-42, which encodes a paired-like homeodomain protein that additionally, regulates fax-1 expression in AVK neurons; FAX-1 exhibits sequence-specific DNA binding in vitro and the FAX-1 DNA binding domain, when fused to the GAL4 transcriptional activator, can positively regulate transcription in yeast one-hybrid assays; FAX-1 is expressed in the nuclei of 18 neurons, including the AVK, AVA, AVB, and AVE interneurons, beginning at mid-embryogenesis and continuing through larval and adult stages; FAX-1 is also seen in two non-neuronal cell types: the distal tip cells (DTCs), from L2 to L4 larval stages, and two pairs of vulval cells in L4 animals. | Paper_evidence | WBPaper00003941 | |||||
WBPaper00026828 | |||||||||
WBPaper00031380 | |||||||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
WBPerson1843 | |||||||||
Date_last_updated | 09 Oct 2008 00:00:00 | ||||||||
Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in several structures, including CEP; hermaphrodite distal tip cell; interneuron; pharyngeal motor neurons; and rect_D. Human ortholog(s) of this gene implicated in enhanced S-cone syndrome and retinitis pigmentosa 37. Is an ortholog of human NR2E3 (nuclear receptor subfamily 2 group E member 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0090059 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||||
DOID:0110399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7974) | ||||||
Molecular_info | Corresponding_CDS | F56E3.4a | |||||||
F56E3.4b | |||||||||
Corresponding_transcript | F56E3.4a.1 | ||||||||
F56E3.4b.1 | |||||||||
Other_sequence | SRC02099_1 | ||||||||
Acan_isotig10071 | |||||||||
EY464040.1 | |||||||||
SR01788 | |||||||||
FC815338.1 | |||||||||
JI475021.1 | |||||||||
CRC12381_1 | |||||||||
JI170219.1 | |||||||||
Associated_feature (11) | |||||||||
Transcription_factor | WBTranscriptionFactor000521 | ||||||||
Experimental_info | RNAi_result (6) | ||||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00002284 | ||||||||
WBCnstr00004291 | |||||||||
WBCnstr00012731 | |||||||||
WBCnstr00013827 | |||||||||
WBCnstr00036970 | |||||||||
Construct_product | WBCnstr00013827 | ||||||||
WBCnstr00021906 | |||||||||
WBCnstr00036970 | |||||||||
Antibody | WBAntibody00000945 | ||||||||
WBAntibody00002352 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (109) | |||||||||
Interaction (20) | |||||||||
Map_info | Map | X | Position | -10.7537 | Error | 0.119879 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | syDf1 | |||||||
yDp14 | |||||||||
Positive_clone | C02A6 | Author_evidence | Wightman BC | ||||||
C38F12 | Author_evidence | Wightman BC | |||||||
F56E3 | Author_evidence | Wightman BC | |||||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
W05A4 | Author_evidence | Wightman BC | |||||||
Negative | Negative_clone | C15C7 | Author_evidence | Wightman BC | |||||
F28B4 | Author_evidence | Wightman BC | |||||||
F40F4 | Author_evidence | Wightman BC | |||||||
Mapping_data | Multi_point | 3537 | |||||||
3538 | |||||||||
3539 | |||||||||
3696 | |||||||||
5603 | |||||||||
Pos_neg_data | 9117 | ||||||||
9118 | |||||||||
Reference (56) | |||||||||
Method | Gene |