WormBase Tree Display for Gene: WBGene00001234
expand all nodes | collapse all nodes | view schema
| WBGene00001234 | Evidence | Author_evidence | Slack FJ | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C47B2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | eif-6 | |||||||
| Sequence_name | C47B2.5 | ||||||||
| Molecular_name | C47B2.5 | ||||||||
| C47B2.5.1 | |||||||||
| CE17565 | |||||||||
| Other_name | CELE_C47B2.5 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | eif-6 | ||||||||
| DB_info | Database | AceView | gene | 1N561 | |||||
| WormQTL | gene | WBGene00001234 | |||||||
| WormFlux | gene | WBGene00001234 | |||||||
| NDB | locus_tag | CELE_C47B2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001234|UniProtKB=O62106 | |||||||
| family | PTHR10784 | ||||||||
| NCBI | gene | 173169 | |||||||
| RefSeq | protein | NM_060871.8 | |||||||
| SwissProt | UniProtAcc | O62106 | |||||||
| TREEFAM | TREEFAM_ID | TF105396 | |||||||
| UniProt_GCRP | UniProtAcc | O62106 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eif | ||||||||
| Allele (23) | |||||||||
| Strain | WBStrain00001619 | ||||||||
| WBStrain00047687 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Contained_in_operon | CEOP1988 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | eif-6 encodes the C. elegans ortholog of vertebrate anti-association factor eIF6 and Saccharomyces cerevisiae Tif6p; EIF-6 is required for lin-4 miRNA-mediated repression of lin-14 and lin-28 mRNA and protein levels and in addition, is required for normal rates of growth and control of cell division in the germ line; eif-6 is expressed ubiquitously (or nearly so) in somatic larval and adult tissues; by orthology to eIF6 and Tif6p, EIF-6 is predicted to be recycled by K10C3.5 and W06E11.4 during maturation of 60S ribosomal subunits, suggesting a link between ribosome assembly and several processes, including miRNA-mediated gene silencing, germline proliferation, and regulation of growth rates; EIF-6 may suppress tumorous growth in the germ line by ensuring robust larval germline proliferation. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00028280 | |||||||||
| WBPaper00028930 | |||||||||
| WBPaper00028931 | |||||||||
| WBPaper00028932 | |||||||||
| WBPaper00029397 | |||||||||
| WBPaper00031006 | |||||||||
| WBPaper00032020 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Jul 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable ribosomal large subunit binding activity. Involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytosol and nucleus. Used to study obesity. Is an ortholog of human EIF6 (eukaryotic translation initiation factor 6). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00001258 | ||||||||
| Molecular_info | Corresponding_CDS | C47B2.5 | |||||||
| Corresponding_transcript | C47B2.5.1 | ||||||||
| Other_sequence (76) | |||||||||
| Associated_feature | WBsf654836 | ||||||||
| WBsf985741 | |||||||||
| WBsf218663 | |||||||||
| WBsf218664 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Chronogram1152 | ||||||||
| Chronogram1473 | |||||||||
| Chronogram1775 | |||||||||
| Expr5524 | |||||||||
| Expr1026159 | |||||||||
| Expr1030782 | |||||||||
| Expr1146640 | |||||||||
| Expr2011263 | |||||||||
| Expr2029499 | |||||||||
| Drives_construct | WBCnstr00002458 | ||||||||
| WBCnstr00004347 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (166) | |||||||||
| Map_info | Map | I | Position | 16.7968 | Error | 0.002957 | |||
| Positive | Positive_clone | C47B2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 94 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00028280 | ||||||||
| WBPaper00029397 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060510 | |||||||||
| WBPaper00061889 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00065861 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
