WormBase Tree Display for Gene: WBGene00000880
expand all nodes | collapse all nodes | view schema
| WBGene00000880 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cyn-4 | Person_evidence | WBPerson466 | |||||
| Sequence_name | F59E10.2 | ||||||||
| Molecular_name | F59E10.2 | ||||||||
| F59E10.2.1 | |||||||||
| CE01596 | |||||||||
| Other_name | mog-6 | CGC_data_submission | |||||||
| cyp-4 | Person_evidence | WBPerson466 | |||||||
| CELE_F59E10.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | cyn-4 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Sep 2004 16:20:03 | WBPerson1971 | Name_change | CGC_name | cyp-4 -> cyn-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cyn | ||||||||
| Allele (39) | |||||||||
| Legacy_information | [C.elegansII] NMK. Cyclophilin family (diverged CsA-binding domain). Cosmid M106. [WS] | ||||||||
| [Graham PL] at 25 degrees fully penetrant Mog: hermaphrodite germline makes only sperm. At 15 degrees sterile non-Mog. Mel if feminized by fem-3. NA1. | |||||||||
| [C.elegansII] q465 : ts Mog, at 25C fully penetrant Mog: hermaphrodite germline makes only sperm. At 15 degrees sterile non-Mog. Mel if feminized by fem-3. NA1. [Graham et al. 1993] | |||||||||
| Strain | WBStrain00022548 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (35) | |||||||||
| Paralog (18) | |||||||||
| Structured_description | Concise_description | cyn-4 encodes a divergent member of the cyclophilin family orthologous to human hCyP-60; in the hermaphrodite germline, cyn-4 activity is required for the sperm/oocyte switch, robust germline proliferation and, redundantly with gld-3, for the mitosis/meiosis decision; in addition, maternal cyn-4 is required for embryogenesis and loss of cyn-4 via RNAi results in morphological defects at early larval stages; in vitro, CYN-4 interacts with the MEP-1 NuRD complex component, as do the MOG-1, -4, and -5 proteins; CYN-4's interaction with MEP-1 is independent of the CYN-4 CBD (central binding domain) which is also dispensable for CYN-4's role in the sperm/oocyte switch; CYN-4 is expressed in the nuclei of both germline and somatic cells; in L4 larvae, CYN-4 is ubiquitously expressed in the mitotic and meiotic regions, but absent from the proximal zone. | Paper_evidence | WBPaper00001883 | |||||
| WBPaper00003252 | |||||||||
| WBPaper00005338 | |||||||||
| WBPaper00024263 | |||||||||
| WBPaper00026884 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 27 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable ubiquitin protein ligase activity. Involved in feminization of hermaphroditic germ-line. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Expressed in body wall musculature; germ line; intestine; pharynx; and uterus. Is an ortholog of human PPIL2 (peptidylprolyl isomerase like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F59E10.2 | |||||||
| Corresponding_transcript | F59E10.2.1 | ||||||||
| Other_sequence (58) | |||||||||
| Associated_feature | WBsf650527 | ||||||||
| WBsf989513 | |||||||||
| WBsf1013110 | |||||||||
| WBsf223854 | |||||||||
| WBsf223855 | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern | Expr1256 | ||||||||
| Expr1257 | |||||||||
| Expr2927 | |||||||||
| Expr2928 | |||||||||
| Expr1016904 | |||||||||
| Expr1030545 | |||||||||
| Expr1152930 | |||||||||
| Expr2010672 | |||||||||
| Expr2028912 | |||||||||
| Drives_construct | WBCnstr00010175 | ||||||||
| WBCnstr00011022 | |||||||||
| WBCnstr00037226 | |||||||||
| Construct_product (3) | |||||||||
| Antibody | WBAntibody00000897 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (97) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | II | Position | 3.13056 | Error | 9.3e-05 | |||
| Positive | Positive_clone | F59E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| M106 | |||||||||
| Mapping_data | Multi_point | 2795 | |||||||
| 2796 | |||||||||
| 4358 | |||||||||
| Pos_neg_data | 7385 | ||||||||
| Reference (27) | |||||||||
| Remark | data extracted from Graham, Schedl & Kimble 1993 | ||||||||
| This gene has been renamed with approval of the CGC (cyp-4->cyn-4) | Person_evidence | WBPerson466 | |||||||
| Method | Gene |
