WormBase Tree Display for Gene: WBGene00000838
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| WBGene00000838 | SMap | S_parent | Sequence | Y108G3AL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cul-3 | Person_evidence | WBPerson1052 | |||||
| Sequence_name | Y108G3AL.1 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | CELE_Y108G3AL.1 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cul-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cul | ||||||||
| Allele (136) | |||||||||
| Strain | WBStrain00001512 | ||||||||
| WBStrain00051108 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP5588 | ||||||||
| Ortholog (43) | |||||||||
| Paralog | WBGene00000836 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000837 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000840 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000841 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000839 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000143 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | cul-3 encodes one of six C. elegans cullins; by homology, CUL-3 is predicted to interact with a RING-finger protein to form the catalytic core of an SCF-type E3-ubiquitin ligase complex required for the ubiquitination and degradation of target proteins; in the early embryo, maternal CUL-3 is essential for degradation of MEI-1, a meiosis-specific subunit of the microtubule-severing katanin complex that is active during meiosis but whose degradation is essential for successful mitotic spindle formation and subsequent zygotic cytokinesis; to effect MEI-1 degradation, CUL-3 interacts with MEL-26, a substrate-specific adaptor protein that also binds MEI-1, thus linking MEI-1 with the CUL-3-containing E3 ligase; CUL-3 activity is regulated by cycles of neddylation and deneddylation that are dependent upon activity of the DCN-1, RBX-1, and RFL-1 gene products; cul-3 mRNA is present at all life stages, with highest levels seen in embryos; expression of a cul-3::GFP transcriptional reporter fusion is detected in many somatic tissues, including the pharynx, intestine, hypodermis, and several different muscle types. | Paper_evidence | WBPaper00002473 | |||||
| WBPaper00005108 | |||||||||
| WBPaper00005914 | |||||||||
| WBPaper00006054 | |||||||||
| WBPaper00006055 | |||||||||
| WBPaper00024507 | |||||||||
| WBPaper00026631 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 11 Jul 2005 00:00:00 | ||||||||
| Automated_description | Enables POZ domain binding activity. Involved in cell development; protein catabolic process; and protein polyubiquitination. Part of Cul3-RING ubiquitin ligase complex. Expressed in head; linker cell; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Is an ortholog of human CUL3 (cullin 3). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4479 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2553) | ||||
| Molecular_info | Corresponding_CDS | Y108G3AL.1a | |||||||
| Y108G3AL.1b | |||||||||
| Y108G3AL.1c | |||||||||
| Y108G3AL.1d | |||||||||
| Corresponding_transcript | Y108G3AL.1a.1 | ||||||||
| Y108G3AL.1a.2 | |||||||||
| Y108G3AL.1b.1 | |||||||||
| Y108G3AL.1c.1 | |||||||||
| Y108G3AL.1d.1 | |||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf999092 | ||||||||
| WBsf999093 | |||||||||
| WBsf999094 | |||||||||
| WBsf1019027 | |||||||||
| WBsf1019028 | |||||||||
| WBsf231307 | |||||||||
| WBsf231308 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Chronogram813 | ||||||||
| Expr1594 | |||||||||
| Expr6878 | |||||||||
| Expr12881 | |||||||||
| Expr1028409 | |||||||||
| Expr1030520 | |||||||||
| Expr1158823 | |||||||||
| Expr2010588 | |||||||||
| Expr2028828 | |||||||||
| Drives_construct | WBCnstr00002369 | ||||||||
| Regulate_expr_cluster | WBPaper00029237:CUL-3_interacting | ||||||||
| Antibody | WBAntibody00000629 | ||||||||
| WBAntibody00000936 | |||||||||
| WBAntibody00001631 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (137) | |||||||||
| Interaction (88) | |||||||||
| Map_info | Map | V | Position | -20.0103 | Error | 9.4e-05 | |||
| Positive | Positive_clone | W01A6 | |||||||
| Y108G3AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Pseudo_map_position | |||||||||
| Reference (55) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
