WormBase Tree Display for Gene: WBGene00000770
expand all nodes | collapse all nodes | view schema
| WBGene00000770 | SMap | S_parent | Sequence | C40H1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | cpb-1 | Person_evidence | WBPerson1574 | |||||
| Sequence_name | C40H1.1 | ||||||||
| Molecular_name | C40H1.1 | ||||||||
| C40H1.1.1 | |||||||||
| CE43522 | |||||||||
| Other_name | CELE_C40H1.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | cpb-1 | ||||||||
| DB_info | Database | AceView | gene | 3K413 | |||||
| WormQTL | gene | WBGene00000770 | |||||||
| WormFlux | gene | WBGene00000770 | |||||||
| NDB | locus_tag | CELE_C40H1.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000770|UniProtKB=Q03571 | |||||||
| family | PTHR12566 | ||||||||
| NCBI | gene | 176310 | |||||||
| RefSeq | protein | NM_066650.6 | |||||||
| SwissProt | UniProtAcc | Q03571 | |||||||
| TREEFAM | TREEFAM_ID | TF317658 | |||||||
| UniProt_GCRP | UniProtAcc | Q03571 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cpb | ||||||||
| Allele (35) | |||||||||
| Strain | WBStrain00062680 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00001481 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000772 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000771 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | cpb-1 encodes a cytoplasmic polyadenylation element binding (CPEB) protein homolog involved in two steps of spermatogenesis; two CPEB proteins have distinct functions in spermatogenesis, with FOG-1 specifying sperm cell fate, and CPB-1 conversely executing that decision, being required for progression through meiosis; cpb-1(RNAi) spermatocytes fail to undergo meiotic cell divisions; CPB-1 protein is present in the germ line just prior to overt spermatogenesis, but once sperm differentiation begins, CPB-1 disappears; CPB-1 physically interacts with EBF, which, like CPEB, regulates genes by binding the 3' UTRs of mRNAs; while CPB-1 is required for spermatogenesis, it is dispensable for oogenesis; this is in contrast to CPEBs in vertebrates (Xenopus), arthropods (Drosophila), and molluscs (Spisula), which all participate in oogenesis. | Paper_evidence | WBPaper00004396 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 13 Dec 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Involved in meiotic cell cycle and spermatogenesis. Located in cytoplasm. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in portal hypertension and primary biliary cholangitis. Is an ortholog of human CPEB2 (cytoplasmic polyadenylation element binding protein 2). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:12236 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21747) | ||||
| DOID:10762 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21747) | ||||||
| DOID:5082 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:21747) | ||||||
| Molecular_info | Corresponding_CDS | C40H1.1 | |||||||
| Corresponding_CDS_history | C40H1.1:wp179 | ||||||||
| C40H1.1:wp200 | |||||||||
| Corresponding_transcript | C40H1.1.1 | ||||||||
| Other_sequence (35) | |||||||||
| Associated_feature | WBsf225547 | ||||||||
| WBsf225548 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00005992 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062678 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002339 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00042257 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011816 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029707 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075629 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1052 | ||||||||
| Expr15932 | |||||||||
| Expr1023268 | |||||||||
| Expr1030474 | |||||||||
| Expr1146248 | |||||||||
| Expr2010475 | |||||||||
| Expr2028715 | |||||||||
| Drives_construct | WBCnstr00037291 | ||||||||
| Construct_product | WBCnstr00037291 | ||||||||
| Antibody | WBAntibody00000326 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (188) | |||||||||
| Interaction (42) | |||||||||
| WBProcess | WBbiopr:00000069 | ||||||||
| Map_info | Map | III | Position | 0.405507 | Error | 0.002887 | |||
| Positive | Positive_clone | C40H1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | sequence connection from [Luitjens C, Wickens MP] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
