WormBase Tree Display for Gene: WBGene00000499
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| WBGene00000499 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y60A3A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | chk-2 | Person_evidence | WBPerson1551 | |||||
| Sequence_name | Y60A3A.12 | ||||||||
| Molecular_name | Y60A3A.12 | ||||||||
| Y60A3A.12.1 | |||||||||
| CE27297 | |||||||||
| Other_name | cds-1 | Accession_evidence | EMBL | AB041996 | |||||
| Ce-chk-2 | Accession_evidence | EMBL | AB049441 | ||||||
| Ce-cds-1 | Accession_evidence | EMBL | AB041996 | ||||||
| CELE_Y60A3A.12 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | chk-2 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | chk | ||||||||
| Allele (152) | |||||||||
| Strain | WBStrain00037735 | ||||||||
| WBStrain00040537 | |||||||||
| WBStrain00000281 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP5496 | ||||||||
| Ortholog (35) | |||||||||
| Paralog | WBGene00011612 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | chk-2 encodes a member of the Cds1/Chk2 checkpoint kinase family, orthologous to human CHK2 (OMIM:604373, mutated in Li-Fraumeni syndrome), that affects pairing between homologous chromosomes during early meiotic prophase, and might function to couple premeiotic S phase with early prophase; CHK-2 is expressed in the germ line. | Paper_evidence | WBPaper00004454 | |||||
| WBPaper00004767 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson48 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be located in cytoplasm and nucleus. Expressed in germline blastomere. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); and germ cell cancer (multiple). Is an ortholog of human CHEK2 (checkpoint kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
| WBPaper00067038 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS296 version of WormBase | ||||||||
| Date_last_updated | 20 Mar 2025 00:00:00 | ||||||||
| Disease_info | Potential_model (11) | ||||||||
| Molecular_info | Corresponding_CDS | Y60A3A.12 | |||||||
| Corresponding_CDS_history | Y60A3A.12:wp47 | ||||||||
| Corresponding_transcript | Y60A3A.12.1 | ||||||||
| Other_sequence (24) | |||||||||
| Associated_feature | WBsf669874 | ||||||||
| WBsf1003378 | |||||||||
| WBsf1003379 | |||||||||
| WBsf1003380 | |||||||||
| WBsf1003381 | |||||||||
| WBsf1021835 | |||||||||
| WBsf1021836 | |||||||||
| WBsf1021837 | |||||||||
| WBsf1021838 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr809 | ||||||||
| Expr815 | |||||||||
| Expr16098 | |||||||||
| Expr1030295 | |||||||||
| Expr1161236 | |||||||||
| Expr2009992 | |||||||||
| Expr2028233 | |||||||||
| Drives_construct | WBCnstr00042759 | ||||||||
| Antibody | WBAntibody00002660 | ||||||||
| Microarray_results (15) | |||||||||
| Expression_cluster (96) | |||||||||
| Interaction (119) | |||||||||
| Map_info | Map | V | Position | 23.9744 | Error | 0.026105 | |||
| Positive | Positive_clone | Y60A3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4216 | |||||||
| Pseudo_map_position | |||||||||
| Reference (49) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
