WormBase Tree Display for Gene: WBGene00000367
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WBGene00000367 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | cca-1 | Person_evidence | WBPerson604 | |||||
Sequence_name | C54D2.5 | ||||||||
Molecular_name (17) | |||||||||
Other_name | CELE_C54D2.5 | Accession_evidence | NDB | BX284606 | |||||
Public_name | cca-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cca | ||||||||
Allele (488) | |||||||||
Strain | WBStrain00035024 | ||||||||
WBStrain00035026 | |||||||||
WBStrain00002849 | |||||||||
WBStrain00022216 | |||||||||
WBStrain00033162 | |||||||||
WBStrain00035498 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Ortholog (45) | |||||||||
Paralog | WBGene00001187 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
WBGene00003558 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00006742 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00006809 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | cca-1 encodes a calcium channel alpha subunit that is homologous to vertebrate T-type calcium channel alpha 1 subunits; CCA-1 is required for regulation of pharyngeal pumping, specifically for the efficient initiation of action potentials in the pharynx in response to excitatory inputs; a CCA-1::GFP fusion protein is expressed strongly in pharyngeal muscle as well as in many neurons, including particular subsets of neurons in the head, pharynx, ventral nerve cord, and anal ganglia. | Paper_evidence | WBPaper00025209 | |||||
WBPaper00025210 | |||||||||
Curator_confirmed | WBPerson480 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 18 Oct 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable low voltage-gated calcium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of nematode pharyngeal pumping. Predicted to be located in neuron projection. Predicted to be part of voltage-gated sodium channel complex. Expressed in several structures, including alimentary muscle; distal tip cell; pharyngeal neurons; serotonergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including cerebellar ataxia type 42; childhood absence epilepsy; and primary hyperaldosteronism. Is an ortholog of human CACNA1I (calcium voltage-gated channel subunit alpha1 I). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:446 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||||
DOID:1825 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1395) | ||||||
DOID:0111742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1394) | ||||||
DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1396) | ||||||
Molecular_info | Corresponding_CDS | C54D2.5a | |||||||
C54D2.5c | |||||||||
C54D2.5d | |||||||||
C54D2.5e | |||||||||
C54D2.5g | |||||||||
Corresponding_CDS_history | C54D2.5b:wp170 | ||||||||
C54D2.5f:wp245 | |||||||||
Corresponding_transcript | C54D2.5a.1 | ||||||||
C54D2.5a.2 | |||||||||
C54D2.5a.3 | |||||||||
C54D2.5c.1 | |||||||||
C54D2.5d.1 | |||||||||
C54D2.5e.1 | |||||||||
C54D2.5g.1 | |||||||||
Other_sequence (29) | |||||||||
Associated_feature (24) | |||||||||
Experimental_info | RNAi_result | WBRNAi00012391 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00043146 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00003371 | ||||||||
WBCnstr00004844 | |||||||||
WBCnstr00004846 | |||||||||
WBCnstr00011900 | |||||||||
Microarray_results (41) | |||||||||
Expression_cluster (144) | |||||||||
Interaction (22) | |||||||||
Map_info | Map | X | Position | -1.05786 | Error | 0.020226 | |||
Positive | Positive_clone | C54D2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4178 | |||||||
4653 | |||||||||
4766 | |||||||||
Pseudo_map_position | |||||||||
Reference (39) | |||||||||
Remark | AF368920 contains the experimentally derived cDNA sequence. It differs in several regards from the sequence predicted from analysis of cosmid C54D2 (product 5). | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |