WormBase Tree Display for Gene: WBGene00000169
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WBGene00000169 | Evidence | Person_evidence | WBPerson548 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F32A5 | ||||||
Identity | Version | 2 | |||||||
Name | CGC_name | aqp-1 | Person_evidence | WBPerson300 | |||||
Sequence_name | F32A5.5 | ||||||||
Molecular_name | F32A5.5a | ||||||||
F32A5.5a.1 | |||||||||
CE29304 | |||||||||
F32A5.5b | |||||||||
CE01275 | |||||||||
F32A5.5b.1 | |||||||||
Other_name | dod-4 | ||||||||
CELE_F32A5.5 | Accession_evidence | NDB | BX284602 | ||||||
Public_name | aqp-1 | ||||||||
DB_info | Database | AceView | gene | 2H526 | |||||
WormQTL | gene | WBGene00000169 | |||||||
WormFlux | gene | WBGene00000169 | |||||||
NDB | locus_tag | CELE_F32A5.5 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00000169|UniProtKB=Q19949 | |||||||
family | PTHR43829 | ||||||||
NCBI | gene | 174190 | |||||||
RefSeq | protein | NM_063109.6 | |||||||
NM_001381493.2 | |||||||||
TREEFAM | TREEFAM_ID | TF313173 | |||||||
TrEMBL | UniProtAcc | Q19949 | |||||||
Q8IG23 | |||||||||
UniProt_GCRP | UniProtAcc | Q19949 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 25 Aug 2004 11:36:28 | WBPerson1971 | Name_change | Other_name | dod-4 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | aqp | ||||||||
Allele (34) | |||||||||
Strain | WBStrain00004916 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Ortholog (40) | |||||||||
Paralog | WBGene00000171 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000176 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00000175 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00000170 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
Structured_description | Concise_description | aqp-1 encodes, by alternative splicing, two isoforms of an aquaglyceroporin required for normally short lifespan; AQP-1 expression is upregulated under daf-2(-) conditions, and loss of AQP-1 function in daf-2 mutant animals results in reduced lifespan; AQP-1 increases glycerol permeability five- to seven-fold when expressed in Xenopus oocytes; AQP-1::GFP fusion proteins are expressed predominantly in the intestine, where they localize to the basolateral plasma membrane, but are also expressed in the pharynx; intestinal expression of AQP-1 is repressed by infection with Pseudomonas aeruginosa. | Paper_evidence | WBPaper00005976 | |||||
WBPaper00028482 | |||||||||
WBPaper00029039 | |||||||||
WBPaper00030907 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson1843 | |||||||||
Date_last_updated | 12 Aug 2007 00:00:00 | ||||||||
Automated_description | Enables channel activity. Involved in defense response to Gram-negative bacterium; glycerol transmembrane transport; and innate immune response. Located in basolateral plasma membrane. Expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) | ||||
DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) | ||||||
Molecular_info | Corresponding_CDS | F32A5.5a | |||||||
F32A5.5b | |||||||||
Corresponding_transcript | F32A5.5a.1 | ||||||||
F32A5.5b.1 | |||||||||
Other_sequence (15) | |||||||||
Associated_feature | WBsf019168 | ||||||||
WBsf650216 | |||||||||
WBsf650217 | |||||||||
WBsf223316 | |||||||||
Experimental_info | RNAi_result | WBRNAi00097044 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00094564 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00014195 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063161 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00031645 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00046077 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00097048 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00094561 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr4771 | ||||||||
Expr1017935 | |||||||||
Expr1149967 | |||||||||
Expr2009379 | |||||||||
Expr2027615 | |||||||||
Drives_construct | WBCnstr00012231 | ||||||||
WBCnstr00017137 | |||||||||
WBCnstr00037691 | |||||||||
Construct_product | WBCnstr00012231 | ||||||||
WBCnstr00017137 | |||||||||
WBCnstr00037691 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (281) | |||||||||
Interaction (92) | |||||||||
Map_info | Map | II | Position | 0.499703 | Error | 3.1e-05 | |||
Positive | Positive_clone | F32A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (15) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |