WormBase Tree Display for Gene: WBGene00000156
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WBGene00000156 | SMap | S_parent | Sequence | K04G2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | apr-1 | Person_evidence | WBPerson419 | |||||
Sequence_name | K04G2.8 | ||||||||
Molecular_name | K04G2.8a | ||||||||
K04G2.8a.1 | |||||||||
CE06102 | |||||||||
K04G2.8b | |||||||||
CE18016 | |||||||||
K04G2.8c | |||||||||
CE51809 | |||||||||
K04G2.8b.1 | |||||||||
K04G2.8c.1 | |||||||||
Other_name | APC | Paper_evidence | WBPaper00044307 | ||||||
CELE_K04G2.8 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | apr-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | apr | ||||||||
Allele (69) | |||||||||
Possibly_affected_by | WBVar02153202 | ||||||||
Legacy_information | [Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01] | ||||||||
Strain | WBStrain00037280 | ||||||||
WBStrain00000140 | |||||||||
WBStrain00008585 | |||||||||
WBStrain00024309 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (75) | |||||||||
Ortholog (41) | |||||||||
Structured_description | Concise_description | The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway. | Paper_evidence (12) | ||||||
Curator_confirmed | WBPerson567 | ||||||||
WBPerson324 | |||||||||
Date_last_updated | 25 May 2011 00:00:00 | ||||||||
Automated_description | Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model (21) | ||||||||
Molecular_info | Corresponding_CDS | K04G2.8a | |||||||
K04G2.8b | |||||||||
K04G2.8c | |||||||||
Corresponding_transcript | K04G2.8a.1 | ||||||||
K04G2.8b.1 | |||||||||
K04G2.8c.1 | |||||||||
Other_sequence | AF013950 | ||||||||
CGC00612_1 | |||||||||
ACC25655_1 | |||||||||
EX555243.1 | |||||||||
CBC06635_1 | |||||||||
Associated_feature | WBsf656598 | ||||||||
WBsf218114 | |||||||||
Experimental_info | RNAi_result (104) | ||||||||
Expr_pattern | Expr1046 | ||||||||
Expr4600 | |||||||||
Expr12119 | |||||||||
Expr12448 | |||||||||
Expr15118 | |||||||||
Expr1028112 | |||||||||
Expr1030085 | |||||||||
Expr1153646 | |||||||||
Expr2009365 | |||||||||
Expr2027601 | |||||||||
Drives_construct | WBCnstr00005188 | ||||||||
WBCnstr00007256 | |||||||||
WBCnstr00009075 | |||||||||
WBCnstr00009116 | |||||||||
WBCnstr00012108 | |||||||||
WBCnstr00016098 | |||||||||
WBCnstr00020198 | |||||||||
WBCnstr00021087 | |||||||||
WBCnstr00037698 | |||||||||
Construct_product | WBCnstr00000526 | ||||||||
WBCnstr00007257 | |||||||||
WBCnstr00007258 | |||||||||
WBCnstr00009057 | |||||||||
WBCnstr00009075 | |||||||||
WBCnstr00012108 | |||||||||
WBCnstr00016098 | |||||||||
WBCnstr00020198 | |||||||||
WBCnstr00021087 | |||||||||
WBCnstr00037698 | |||||||||
Antibody | WBAntibody00000276 | ||||||||
WBAntibody00000277 | |||||||||
Microarray_results (25) | |||||||||
Expression_cluster (127) | |||||||||
Interaction (179) | |||||||||
WBProcess | WBbiopr:00000073 | ||||||||
Map_info | Map | I | Position | 2.43771 | Error | 0.002342 | |||
Positive | Positive_clone | K04G2 | Person_evidence | WBPerson524 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | Multi_point | 4159 | |||||||
4893 | |||||||||
5616 | |||||||||
Pseudo_map_position | |||||||||
Reference (108) | |||||||||
Picture | WBPicture0000013084 | ||||||||
Remark | Data extracted from Rocheleau et al. (1997) | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |