WormBase Tree Display for Gene: WBGene00006760
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WBGene00006760 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_V | ||||||
Identity | Version | 2 | |||||||
Name | CGC_name | unc-23 | Person_evidence | WBPerson261 | |||||
Sequence_name | H14N18.1 | ||||||||
Molecular_name | H14N18.1a | ||||||||
H14N18.1a.1 | |||||||||
CE17973 | |||||||||
H14N18.1b | |||||||||
CE33124 | |||||||||
H14N18.1c | |||||||||
CE37777 | |||||||||
H14N18.1b.1 | |||||||||
H14N18.1c.1 | |||||||||
Other_name | vab-4 | ||||||||
bag-2 | Paper_evidence | WBPaper00048629 | |||||||
CELE_H14N18.1 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | unc-23 | ||||||||
DB_info | Database | AceView | gene | 5J419 | |||||
WormQTL | gene | WBGene00006760 | |||||||
WormFlux | gene | WBGene00006760 | |||||||
NDB | locus_tag | CELE_H14N18.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00006760|UniProtKB=O61980 | |||||||
family | PTHR12334 | ||||||||
NCBI | gene | 179272 | |||||||
RefSeq | protein | NM_072906.7 | |||||||
NM_182342.6 | |||||||||
NM_001392570.1 | |||||||||
TREEFAM | TREEFAM_ID | TF102012 | |||||||
TrEMBL | UniProtAcc | Q5TKA9 | |||||||
Q86S24 | |||||||||
O61980 | |||||||||
UniProt_GCRP | UniProtAcc | O61980 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 03 Nov 2015 10:56:26 | WBPerson2970 | Name_change | Other_name | bag-2 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00142919 | ||||||||
Allele (62) | |||||||||
Legacy_information | e25 : `benthead' progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally hence very poor forward movement good reverse movement. Egl. ES3 (adult) ME1. NA8 (e324 : resembles e25; e611 (pka vab-4 : incompletely penetrant allele) etc.). | ||||||||
See also e25, e462, e478, e611, e621, e988, e1182, e2154 | |||||||||
[C.elegansII] e25 : "benthead" phenotype, progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally, hence very poor forward movement, good reverse movement; defects in muscle attachment (Mua); Egl. Phenotype partly suppressed by growth in liquid. ES3 (adult) ME1. OA>10: e324 (resembles e25), e611 (pka vab-4, impenetrant allele), e988, e2154 etc. [Waterston et al. 1980; CB; DR; NJ] | |||||||||
Strain | WBStrain00032000 | ||||||||
WBStrain00033526 | |||||||||
WBStrain00034712 | |||||||||
WBStrain00003976 | |||||||||
WBStrain00003958 | |||||||||
WBStrain00004081 | |||||||||
WBStrain00004149 | |||||||||
WBStrain00004186 | |||||||||
WBStrain00005873 | |||||||||
WBStrain00005890 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (36) | |||||||||
Structured_description | Concise_description | unc-23 encodes a protein with similarity to the BAG2 (BCL2 AnthaGene) protein that functions to negatively regulate proteosomal degradation by the E3 ubiquitin ligase and Hsp70 co-chaperone CHIP (Carboxyl-terminus of Hsp70 Interacting Protein); in C. elegans, unc-23 is required for proper attachment of the anterior body wall musculature to the overlying hypodermis. | Paper_evidence | WBPaper00040313 | |||||
WBPaper00000461 | |||||||||
WBPaper00003943 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 29 Oct 2015 00:00:00 | ||||||||
Automated_description | Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Expressed in several structures, including anal depressor muscle; excretory canal; pharynx; touch receptor neurons; and vulva. Is an ortholog of human BAG2 (BAG cochaperone 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | H14N18.1a | |||||||
H14N18.1b | |||||||||
H14N18.1c | |||||||||
Corresponding_transcript | H14N18.1a.1 | ||||||||
H14N18.1b.1 | |||||||||
H14N18.1c.1 | |||||||||
Other_sequence (11) | |||||||||
Associated_feature | WBsf647031 | ||||||||
WBsf647032 | |||||||||
WBsf661014 | |||||||||
WBsf661015 | |||||||||
WBsf661510 | |||||||||
WBsf981973 | |||||||||
WBsf232176 | |||||||||
WBsf232177 | |||||||||
WBsf232178 | |||||||||
Experimental_info | RNAi_result (14) | ||||||||
Expr_pattern | Expr11891 | ||||||||
Expr12480 | |||||||||
Expr1012508 | |||||||||
Expr1032833 | |||||||||
Expr1153142 | |||||||||
Expr2017856 | |||||||||
Expr2035992 | |||||||||
Drives_construct | WBCnstr00019716 | ||||||||
WBCnstr00019717 | |||||||||
WBCnstr00034167 | |||||||||
Construct_product | WBCnstr00021438 | ||||||||
WBCnstr00034167 | |||||||||
Microarray_results (28) | |||||||||
Expression_cluster (193) | |||||||||
Interaction (27) | |||||||||
Map_info | Map | V | Position | 1.8633 | Error | 0.014042 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mDf1 | |||||||
sDf29 | |||||||||
Positive_clone | H14N18 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Negative | Outside_rearr | nDf42 | |||||||
Mapping_data | 2_point | 129 | |||||||
840 | |||||||||
841 | |||||||||
Multi_point (26) | |||||||||
Pos_neg_data | 1740 | ||||||||
1778 | |||||||||
1809 | |||||||||
3114 | |||||||||
3599 | |||||||||
5158 | |||||||||
6768 | |||||||||
303 | |||||||||
859 | |||||||||
863 | |||||||||
2136 | |||||||||
9126 | |||||||||
Reference (57) | |||||||||
Remark | Sequence connection from [Rahmani P, Moerman DG] | ||||||||
Method | Gene |