WormBase Tree Display for Gene: WBGene00006812
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WBGene00006812 | SMap | S_parent | Sequence | F25C8 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | unc-80 | Person_evidence | WBPerson261 | |||||
Sequence_name | F25C8.3 | ||||||||
Molecular_name (15) | |||||||||
Other_name | CELE_F25C8.3 | Accession_evidence | NDB | BX284605 | |||||
Public_name | unc-80 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 13 Nov 2007 10:02:04 | WBPerson2970 | Event | Acquires_merge | WBGene00009105 | ||||
Acquires_merge | WBGene00009105 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Reference_allele | WBVar00143879 | ||||||||
Allele (316) | |||||||||
Legacy_information | e1272 : slightly sluggish tends to pause good movement. ES1 ME3. NA2 (e1069). | ||||||||
See also e1069, e1272 | |||||||||
[C.elegansII] e1272 : slightly sluggish, tends to pause ("fainter"), good movement; hypersensitive to volatile anaesthetics.ES1 ME3. OA2: e1069, m513. [Sedensky and Meneely 1987; Morgan et al. 1991; CW] | |||||||||
Strain | WBStrain00032777 | ||||||||
WBStrain00040621 | |||||||||
WBStrain00004238 | |||||||||
WBStrain00004286 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (35) | |||||||||
Structured_description | Concise_description | unc-80 encodes a novel protein, conserved amongst C. elegans, Drosophila, and vertebrates; unc-79 functions in a pathway with unc-77 and nca-2, which encode alpha-1 subunits of voltage-insensitive cation leak channels, to regulate presynaptic activation and thus, locomotion and the response to specific volatile anesthetics; co-expression of UNC-77 and UNC-80 in HEK293T cells results in increased UNC-77 channel activity, in a manner consistent with UNC-77 and UNC-80 functioning as an ion leak channel; an unc-80::gfp reporter fusion is expressed in many sensory and all motoneurons; in the nerve ring and in dorsal and ventral nerve cords, UNC-80 localizes to specific axonal regions, but not to synapses; UNC-80, UNC-77, and UNC-79, an additional novel protein believed to act in the same pathway, reciprocally regulate their expression levels in neurons. | Paper_evidence | WBPaper00001281 | |||||
WBPaper00031000 | |||||||||
WBPaper00031592 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 22 Jun 2010 00:00:00 | ||||||||
Automated_description | Enables monoatomic cation channel activity. Involved in several processes, including monoatomic cation homeostasis; positive regulation of locomotion; and response to anesthetic. Located in axon. Part of cation channel complex. Expressed in excretory canal; hermaphrodite distal tip cell; nervous system; and non-striated muscle. Is an ortholog of human UNC80 (unc-80 homolog, NALCN channel complex subunit). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | EFO:MONDO:0014176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:26582) | ||||
Molecular_info | Corresponding_CDS | F25C8.3a | |||||||
F25C8.3b | |||||||||
F25C8.3c | |||||||||
F25C8.3d | |||||||||
F25C8.3e | |||||||||
Corresponding_CDS_history | F25C8.3:wp87 | ||||||||
F25C8.3:wp109 | |||||||||
F25C8.3a:wp182 | |||||||||
Corresponding_transcript | F25C8.3a.1 | ||||||||
F25C8.3b.1 | |||||||||
F25C8.3c.1 | |||||||||
F25C8.3d.1 | |||||||||
F25C8.3e.1 | |||||||||
Other_sequence | JO470118.1 | ||||||||
Dviv_isotig26964 | |||||||||
JI163971.1 | |||||||||
Dviv_isotig25731 | |||||||||
JI168394.1 | |||||||||
JI173071.1 | |||||||||
Dviv_isotig28087 | |||||||||
JI170851.1 | |||||||||
JI167492.1 | |||||||||
FC546799.1 | |||||||||
JI166934.1 | |||||||||
MI03305 | |||||||||
DN152914.1 | |||||||||
BE239030.1 | |||||||||
HBC19296_1 | |||||||||
MIC02836_1 | |||||||||
Acan_isotig08811 | |||||||||
Dviv_isotig30175 | |||||||||
JI163928.1 | |||||||||
Oden_isotig21057 | |||||||||
JI477398.1 | |||||||||
FC546792.1 | |||||||||
ACC10280_1 | |||||||||
JI168396.1 | |||||||||
FC543065.1 | |||||||||
Associated_feature | WBsf647771 | ||||||||
WBsf662284 | |||||||||
WBsf662285 | |||||||||
WBsf662286 | |||||||||
WBsf1003660 | |||||||||
WBsf1003661 | |||||||||
WBsf1003662 | |||||||||
WBsf1022024 | |||||||||
WBsf1022025 | |||||||||
WBsf1022026 | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern | Expr4994 | ||||||||
Expr8059 | |||||||||
Expr8061 | |||||||||
Expr16166 | |||||||||
Expr1026757 | |||||||||
Expr1032878 | |||||||||
Expr1149400 | |||||||||
Expr2017910 | |||||||||
Expr2036046 | |||||||||
Drives_construct | WBCnstr00000610 | ||||||||
WBCnstr00001622 | |||||||||
WBCnstr00013085 | |||||||||
WBCnstr00042790 | |||||||||
Construct_product | WBCnstr00000610 | ||||||||
Microarray_results (26) | |||||||||
Expression_cluster (207) | |||||||||
Interaction (41) | |||||||||
Map_info | Map | V | Position | 25.581 | Error | 0.021198 | |||
Positive | Positive_clone | F25C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 1568 | |||||||
Reference (46) | |||||||||
Method | Gene |