WormBase Tree Display for Gene: WBGene00008400
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| WBGene00008400 | SMap | S_parent | Sequence | D2005 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | drh-3 | Person_evidence | WBPerson524 | |||||
| WBPerson637 | |||||||||
| WBPerson419 | |||||||||
| Sequence_name | D2005.5 | ||||||||
| Molecular_name | D2005.5 | ||||||||
| D2005.5.1 | |||||||||
| CE36120 | |||||||||
| Other_name | ekl-3 | Person_evidence | WBPerson524 | ||||||
| WBPerson637 | |||||||||
| WBPerson419 | |||||||||
| CELE_D2005.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | drh-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 Jul 2005 13:34:00 | WBPerson2970 | Name_change | CGC_name | ekl-3 | ||||
| 3 | 22 Nov 2005 11:36:22 | WBPerson2970 | Name_change | CGC_name | drh-3 | ||||
| Other_name | ekl-3 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | drh | ||||||||
| Allele (85) | |||||||||
| Strain | WBStrain00040442 | ||||||||
| WBStrain00040467 | |||||||||
| WBStrain00040472 | |||||||||
| WBStrain00040473 | |||||||||
| WBStrain00040474 | |||||||||
| WBStrain00040878 | |||||||||
| WBStrain00006414 | |||||||||
| WBStrain00006429 | |||||||||
| WBStrain00006431 | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Contained_in_operon | CEOP1979 | ||||||||
| Ortholog (45) | |||||||||
| Paralog | WBGene00000939 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00001090 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | drh-3 encodes a DEAH/D-box helicase; drh-3 is required for germline RNAi and for production of several types of endogenous small RNA molecules; in addition, drh-3 plays an essential role in germ cell proliferation, gamete formation, and chromosome segregation; drh-3 is also involved in resistance to X-ray irradiation and genetic studies suggest that drh-3 may also control expression of small RNAs that regulate cell fate specification via Ras-ERK signaling; DRH-3 interacts with the DCR-1 endoribonuclease essential for several distinct small-RNA-mediated silencing pathways and with the RRF-1 RNA-directed RNA polymerase. | Paper_evidence | WBPaper00005368 | |||||
| WBPaper00027057 | |||||||||
| WBPaper00031021 | |||||||||
| WBPaper00031057 | |||||||||
| WBPaper00031214 | |||||||||
| WBPaper00031487 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Sep 2008 00:00:00 | ||||||||
| Automated_description | Enables several functions, including ATP hydrolysis activity; ATP-dependent activity, acting on RNA; and RNA binding activity. Involved in P granule assembly; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in P granule; condensed nuclear chromosome; and metaphase plate. Expressed widely. Is an ortholog of human RIGI (RNA sensor RIG-I). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Potential_model | EFO:MONDO:0008429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19102) | ||||
| Molecular_info | Corresponding_CDS | D2005.5 | |||||||
| Corresponding_CDS_history | D2005.5:wp80 | ||||||||
| D2005.5:wp114 | |||||||||
| Corresponding_transcript | D2005.5.1 | ||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf643487 | ||||||||
| WBsf1010148 | |||||||||
| WBsf218072 | |||||||||
| Experimental_info | RNAi_result (30) | ||||||||
| Expr_pattern | Expr4899 | ||||||||
| Expr7853 | |||||||||
| Expr8818 | |||||||||
| Expr9631 | |||||||||
| Expr1027221 | |||||||||
| Expr1033638 | |||||||||
| Expr1147425 | |||||||||
| Expr2011089 | |||||||||
| Expr2029325 | |||||||||
| Drives_construct | WBCnstr00032992 | ||||||||
| Construct_product | WBCnstr00032992 | ||||||||
| Regulate_expr_cluster | WBPaper00045050:drh-3 (ne4253)_downregulated | ||||||||
| WBPaper00045050:drh-3 (ne4253)_upregulated | |||||||||
| WBPaper00053888:drh-3(rrr2)_downregulated | |||||||||
| WBPaper00053888:drh-3(rrr2)_upregulated | |||||||||
| Antibody | WBAntibody00001328 | ||||||||
| WBAntibody00001998 | |||||||||
| WBAntibody00001999 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (132) | |||||||||
| Interaction (55) | |||||||||
| WBProcess | WBbiopr:00000057 | ||||||||
| WBbiopr:00000081 | |||||||||
| Map_info | Map | I | Position | 2.36836 | Error | 0.002116 | |||
| Positive | Positive_clone | D2005 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5503 | |||||||
| 4145 | |||||||||
| 4160 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (61) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
