WormBase Tree Display for Gene: WBGene00004951
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WBGene00004951 | SMap | S_parent | Sequence | K10B3 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | spc-1 | Person_evidence | WBPerson427 | |||||
Sequence_name | K10B3.10 | ||||||||
Molecular_name | K10B3.10a | ||||||||
K10B3.10a.1 | |||||||||
CE07373 | |||||||||
K10B3.10b | |||||||||
CE46456 | |||||||||
K10B3.10b.1 | |||||||||
Other_name | imo-1 | ||||||||
CELE_K10B3.10 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | spc-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spc | ||||||||
Allele (142) | |||||||||
Possibly_affected_by | WBVar02152908 | ||||||||
Legacy_information | [Norman KR] imo for incomplete morphogenesis. imo-1 (ra409) homozygotes are L1 lethals due to a defect in embryonic elongation. | ||||||||
re-named to spc-1 for spectrin [sdm/jah] | |||||||||
Complementation_data | [Norman KR] complements dpy-3 (e27), dpy-7 (sc27), lon-2 (e678), unc-2 (e55), unc- 20 (e112), unc-78 (e1217) | ||||||||
Strain | WBStrain00005882 | ||||||||
WBStrain00034760 | |||||||||
WBStrain00047279 | |||||||||
WBStrain00047277 | |||||||||
WBStrain00047274 | |||||||||
WBStrain00047278 | |||||||||
RNASeq_FPKM (73) | |||||||||
GO_annotation (17) | |||||||||
Ortholog (42) | |||||||||
Paralog (13) | |||||||||
Structured_description | Concise_description | spc-1 encodes the C. elegans alpha spectrin ortholog; during development, spc-1 activity is required for body morphogenesis, formation of body wall muscles, locomotion, and larval development. | Paper_evidence | WBPaper00004127 | |||||
WBPaper00005321 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 31 Jan 2007 00:00:00 | ||||||||
Automated_description | Predicted to enable actin filament binding activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and regulation of growth. Predicted to be located in several cellular components, including cell junction; cortical actin cytoskeleton; and plasma membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 5 and hereditary spherocytosis type 3. Is an ortholog of human SPTAN1 (spectrin alpha, non-erythrocytic 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0080438 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||||
DOID:0110918 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||||
DOID:12971 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11272) | ||||||
DOID:0081400 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11273) | ||||||
Molecular_info | Corresponding_CDS | K10B3.10a | |||||||
K10B3.10b | |||||||||
Corresponding_transcript | K10B3.10a.1 | ||||||||
K10B3.10b.1 | |||||||||
Other_sequence (138) | |||||||||
Associated_feature (24) | |||||||||
Experimental_info | RNAi_result | WBRNAi00060090 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00060091 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00060092 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00025934 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00050477 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00000485 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00080495 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00008979 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00022774 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00060093 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00035308 | ||||||||
WBCnstr00041562 | |||||||||
Construct_product | WBCnstr00035308 | ||||||||
WBCnstr00041562 | |||||||||
Regulate_expr_cluster | WBPaper00057041:spc-1(cas971)_downregulated | ||||||||
WBPaper00057041:spc-1(cas971)_upregulated | |||||||||
Antibody | WBAntibody00000528 | ||||||||
Microarray_results (22) | |||||||||
Expression_cluster (218) | |||||||||
Interaction (480) | |||||||||
WBProcess | WBbiopr:00000006 | ||||||||
Map_info | Map | X | Position | -12.1435 | Error | 0.053657 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDp33 | |||||||
Positive_clone | K10B3 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
M01F12 | |||||||||
Mapping_data | Multi_point | 3805 | |||||||
3806 | |||||||||
5603 | |||||||||
Pos_neg_data | 10240 | ||||||||
Reference (35) | |||||||||
Method | Gene |