WormBase Tree Display for Gene: WBGene00003242
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| WBGene00003242 | SMap | S_parent | Sequence | C37C3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mig-6 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C37C3.6 | ||||||||
| Molecular_name | C37C3.6a | ||||||||
| C37C3.6a.1 | |||||||||
| CE17535 | |||||||||
| C37C3.6b | |||||||||
| CE17536 | |||||||||
| C37C3.6c | |||||||||
| CE30735 | |||||||||
| C37C3.6a.2 | |||||||||
| C37C3.6b.1 | |||||||||
| C37C3.6c.1 | |||||||||
| Other_name | ppn-1 | ||||||||
| cpg-17 | Paper_evidence | WBPaper00053350 | |||||||
| CELE_C37C3.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | mig-6 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00003242 | |||||
| WormFlux | gene | WBGene00003242 | |||||||
| NDB | locus_tag | CELE_C37C3.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003242|UniProtKB=O76840 | |||||||
| family | PTHR13723 | ||||||||
| NCBI | gene | 179162 | |||||||
| RefSeq | protein | NM_001383344.2 | |||||||
| NM_072616.7 | |||||||||
| NM_171931.7 | |||||||||
| SwissProt | UniProtAcc | O76840 | |||||||
| TREEFAM | TREEFAM_ID | TF316874 | |||||||
| UniProt_GCRP | UniProtAcc | O76840 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 31 Mar 2009 10:57:03 | WBPerson1847 | Event | Acquires_merge | WBGene00016498 | ||||
| Acquires_merge | WBGene00016498 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (220) | |||||||||
| Legacy_information | [Francis R] migration defect | ||||||||
| [C.elegansII] e1931 : distal tip cells fail to migrate, sterile. OA2: oz90, oz113[Hedgecock et al. 1987; NJ; BS] | |||||||||
| Complementation_data | [Francis R] fails to complement mig-6(oz90), mig-6(e1931) | ||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (12) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00000082 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000083 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001650 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00086562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009958 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020567 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021171 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003248 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | mig-6 encodes at least two protein isoforms (long and short) that are highly similar to the extracellular matrix proteins papilin and lacunin; mig-6 is an essential gene required for embryonic hypodermal cell enclosure and normal excretory canal cell function in L1 larvae; MIG-6(S) activity is required cell nonautonomously for the ventral to dorsal phase of distal tip cell (DTC) migration and appears to function by regulating the localization of the MIG-17 metalloproteinase and possibly the amount of functional EMB-9 or LET-2 collagen in the basement membrane; MIG-6(L) activity is required cell autonomously in the DTCs for regulating the rate at which the DTCs migrate at all phases; MIG-6 is expressed in embryos and larvae; in embryos, MIG-6 is expressed in body wall muscles, where it appears to localize to the cell surface; in larvae, MIG-6 is detected in the basement membranes of the gonad primordium, pharynx, and intestine. | Paper_evidence | WBPaper00000978 | |||||
| WBPaper00004504 | |||||||||
| WBPaper00033006 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Mar 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. Is an ortholog of human PAPLN (papilin, proteoglycan like sulfated glycoprotein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C37C3.6a | |||||||
| C37C3.6b | |||||||||
| C37C3.6c | |||||||||
| Corresponding_transcript | C37C3.6a.1 | ||||||||
| C37C3.6a.2 | |||||||||
| C37C3.6b.1 | |||||||||
| C37C3.6c.1 | |||||||||
| Other_sequence (124) | |||||||||
| Associated_feature (33) | |||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00007509 | ||||||||
| WBCnstr00007510 | |||||||||
| WBCnstr00007584 | |||||||||
| WBCnstr00007585 | |||||||||
| WBCnstr00037954 | |||||||||
| WBCnstr00041156 | |||||||||
| Antibody | WBAntibody00001742 | ||||||||
| Microarray_results (42) | |||||||||
| Expression_cluster (269) | |||||||||
| Interaction (93) | |||||||||
| Map_info | Map | V | Position | 0.911478 | Error | 0.000657 | |||
| Positive | Positive_clone | C37C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3160 | |||||||
| 3162 | |||||||||
| 5021 | |||||||||
| Reference (32) | |||||||||
| Method | Gene |
