WormBase Tree Display for Gene: WBGene00002335
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| WBGene00002335 | SMap | S_parent | Sequence | ZK792 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-60 | Person_evidence | WBPerson36 | |||||
| Sequence_name | ZK792.6 | ||||||||
| Molecular_name | ZK792.6 | ||||||||
| ZK792.6.1 | |||||||||
| CE03827 | |||||||||
| Other_name | lin-34 | ||||||||
| CELE_ZK792.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | let-60 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Laboratory | BC | ||||||||
| Reference_allele | WBVar00241691 | ||||||||
| Allele (70) | |||||||||
| Possibly_affected_by | WBVar02158837 | ||||||||
| Legacy_information | s59 : mid-larval lethal (leaky). NA1. | ||||||||
| Mid larval (leaky) | |||||||||
| n1046sd amber non-null : adult hermaphrodite Muv (penetrance 57%) normal vulva with one to three large additional protrusions n1046/+ 17% Muv. ES2. Male gross morphology wildtype ME1. NA1. | |||||||||
| See also n1046, s59, s1124, s1155 | |||||||||
| [Marra MA] Developmental arrest stage 7 days after egg lay at room temperature: s2336 homozygote = L3 larva; s2336/sDf10 = L2 larva | |||||||||
| [C.elegansII] s59 : mid-larval lethal (leaky, escapers non-Vul). OA>10 (recessive): s1124 (strongest allele, both homozygote and hemizygote arrest as rod-like early larva; rare escapers die as Vul adult), s2336 (homozygote L3 arrest, hemizygote L2 arrest), s1155, n2021 (viable, 14% Vul), etc. Weak lf mutations have mating defects.Also dominant negative alleles, OA8: sy93dm (dominant Vul, viable), sy99 (dominant Vul,recessive lethal), sy92 (weaker dominant, recessive lethal), etc.Also gf alleles, OA>5: n1046sd,amb (pka lin-34, non-null; adult hermaphrodite Muv(penetrance 57%), normal vulva with one to three large additional protrusions; n1046/+17% Muv. ES2. Male gross morphology wildtype, ME1),n1700, sy130 (all identical to n1046), ga89ts(at 25C 57% Muv, near-sterile, ME0). Cloned: encodes 143 aa ras protein. let-60:lacZ fusion indicates complex developmental expression, multiple functions. Extensive molecular and developmental analysis. [Rogalski et al. 1982; Han and Sternberg 1990, 1991;Beitel et al. 1990; BC; MH; MT; PS; SD] | |||||||||
| Complementation_data | [Marra MA] s2336 fails to complement let-60(s1124) | ||||||||
| Strain (47) | |||||||||
| Component_of_genotype | WBGenotype00000028 | ||||||||
| WBGenotype00000029 | |||||||||
| WBGenotype00000030 | |||||||||
| WBGenotype00000031 | |||||||||
| WBGenotype00000038 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (48) | |||||||||
| Contained_in_operon | CEOP4472 | ||||||||
| Ortholog (44) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | let-60 encodes a member of the GTP-binding RAS protooncogene family; let-60 activity is required for viability, vulval development, spicule development, germ line meiotic progression, posterior development of the hypodermis, chemotaxis, sex myoblast migration, and muscle membrane extension; let-60 acts genetically downstream of let-23 with respect to vulval development and upstream of the MAPK pathway with respect to chemotaxis; let-60 is expressed in neural, muscle, and hypodermal lineages. | Paper_evidence | WBPaper00001355 | |||||
| WBPaper00001356 | |||||||||
| WBPaper00001366 | |||||||||
| WBPaper00002043 | |||||||||
| WBPaper00002224 | |||||||||
| WBPaper00002552 | |||||||||
| WBPaper00003049 | |||||||||
| WBPaper00003955 | |||||||||
| WBPaper00027119 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 06 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables GTP binding activity; phospholipase binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including learning or memory; positive regulation of receptor localization to synapse; and positive regulation of vulval development. Located in cell cortex. Expressed in several structures, including gonad; head neurons; pharyngeal muscle cell; vulval cell; and vulval precursor cell. Used to study RASopathy and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); and malignant astrocytoma (multiple). Is an ortholog of human HRAS (HRas proto-oncogene, GTPase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00054805 | ||||
| WBPaper00060633 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Jun 2021 00:00:00 | ||||||||
| DOID:10283 | Homo sapiens | Paper_evidence | WBPaper00006401 | ||||||
| Accession_evidence | OMIM | 614731 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Aug 2020 00:00:00 | ||||||||
| DOID:0080690 | Homo sapiens | Paper_evidence | WBPaper00045088 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 09 Jul 2020 00:00:00 | ||||||||
| Potential_model (55) | |||||||||
| Disease_relevance | Mutations in the human ortholog of elegans ras-1, the oncogene RRAS2, are associated with ovarian carcinoma; Also, pathogenesis studies of the human fungal pathogen, Cryptococcus neoformans, using C. elegans as a substitute host, indicate that mutants for several neoformans genes, including ras1 are hypo-virulent, implicating these genes in pathogenesis. | Homo sapiens | Paper_evidence | WBPaper00027034 | |||||
| WBPaper00005590 | |||||||||
| Accession_evidence | OMIM | 600098 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 May 2012 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000070 | ||||||||
| WBDOannot00000498 | |||||||||
| WBDOannot00000779 | |||||||||
| WBDOannot00000788 | |||||||||
| WBDOannot00000854 | |||||||||
| WBDOannot00000950 | |||||||||
| WBDOannot00000955 | |||||||||
| WBDOannot00000967 | |||||||||
| WBDOannot00000968 | |||||||||
| Molecular_info | Corresponding_CDS | ZK792.6 | |||||||
| Corresponding_transcript | ZK792.6.1 | ||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf997905 | ||||||||
| WBsf997906 | |||||||||
| WBsf1018241 | |||||||||
| WBsf1018242 | |||||||||
| WBsf230914 | |||||||||
| WBsf230915 | |||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | IV | Position | 5.20976 | Error | 0.003924 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C33B8 | |||||||
| ZK792 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 1671 | |||||||
| Multi_point (12) | |||||||||
| Pos_neg_data (17) | |||||||||
| Reference (584) | |||||||||
| Method | Gene |
