| WBGene00006952 | SMap | S_parent | Sequence | ZK377 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | wrt-6 | Person_evidence | WBPerson83 |
| | | Sequence_name | ZK377.1 |
| | | Molecular_name | ZK377.1 |
| | | | ZK377.1.1 |
| | | | CE37175 |
| | | Other_name | ZK377 | Paper_evidence | WBPaper00002823 |
| | | | CELE_ZK377.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | wrt-6 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | wrt |
| | Allele (39) |
| | Possibly_affected_by | WBVar02157903 |
| | Strain | WBStrain00047061 |
| | | WBStrain00052695 |
| | RNASeq_FPKM (74) |
| | GO_annotation (11) |
| | Ortholog (46) |
| | Paralog (24) |
| | Structured_description | Concise_description | wrt-6 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Wart domain, an short region of low-complexitysequence, and a Hint/Hog domain; WRT-6 is expressed in sheath and socketcells of anterior sensilla, seam cells, and hypodermis; the Hint/Hogdomain is predicted to cut WRT-6 into two halves and then covalentlylink cholesterol to the C-terminus of the Wart domain; the Wart domainis predicted to form a cysteine-crosslinked protein involved inintercellular signalling, and it has subtle similarity to the N-terminalHedge domain of HEDGEHOG proteins; WRT-6 is weakly required for normalmolting; WRT-6 is also required for normal growth to full size andlocomotion; all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking. | Paper_evidence | WBPaper00003717 |
| | | | | | WBPaper00026841 |
| | | | | | WBPaper00027263 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 05 Nov 2006 00:00:00 |
| | | Automated_description | Predicted to enable peptidase activity. Predicted to be involved in cell-cell signaling; protein autoprocessing; and system development. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in anterior ganglion (ant); hypodermis; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase |
| | | | | Date_last_updated | 24 Apr 2024 00:00:00 |
| Disease_info | Potential_model (22) |
| Molecular_info | Corresponding_CDS | ZK377.1 |
| | Corresponding_CDS_history | ZK377.1:wp128 |
| | Corresponding_transcript | ZK377.1.1 |
| | Other_sequence | Tcol_isotig15559 |
| | | JI171270.1 |
| | | Name_isotig06845 |
| | | MI05621 |
| | | GR15773 |
| | Associated_feature (11) |
| Experimental_info | RNAi_result | WBRNAi00077012 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00038276 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021983 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076985 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089220 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059384 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr646 |
| | | Expr1026678 |
| | | Expr1032964 |
| | | Expr1162811 |
| | | Expr2018081 |
| | | Expr2036219 |
| | Drives_construct | WBCnstr00008615 |
| | | WBCnstr00012471 |
| | | WBCnstr00034076 |
| | Construct_product | WBCnstr00034076 |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:clk-1(qm30)_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036231:long-telomeres_downregulated |
| | | WBPaper00036738:4uM_Heme_downregulated |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_embryo_enriched |
| | | WBPaper00037950:hypodermis_embryo_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00040285:H2S_12hr_downregulated |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00042034:NO_upregulated_hsf-1(sy441) |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042477:prp-8(RNAi)_downregulated_RNAseq |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00043945:MeHg_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_upregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045017:blmp-1(tm548)_downregulated |
| | | WBPaper00045050:drh-3 (ne4253)_upregulated |
| | | WBPaper00045257:bar-1(ga80)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045420:fertilization_upregulated_transcript |
| | | WBPaper00046499:AMPK_regulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set2 |
| | | WBPaper00046805:P-granule-RNAi_downregulated_Set1 |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated_skn-1-dependent |
| | | WBPaper00047132:skn-1(RNAi)_downregulated_glp-1(ts)-dependent |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049266:trx-1(ok1449)_regulated_oxidative-stressed |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050080:rbr-2(tm3141)_upregulated |
| | | WBPaper00050109:rBmTX14_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050801:DAF-12_dauer_regulome |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050801:SET-4_dauer_regulome |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051021:4-bromodiphenyl-ether_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00051404:alg-2(ok304)_downregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053154:human-amyloid-beta_tau_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053368:F.oxysporum_regulated |
| | | WBPaper00053388:dauer_regulated_Cluster6 |
| | | WBPaper00053402:cco-1(RNAi)_downregulated |
| | | WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054410:set-9(rw5)_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00055013:hmg-4(RNAi)_downregulated |
| | | WBPaper00055013:spt-16(RNAi)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055386:eat-2(ad465)_upregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00055941:nuo-6(qm200)_downregulated |
| | | WBPaper00055944:C.butyricum_vs_OP50_downregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056039:ptrn-1(tm5597)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_adult |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L3 |
| | | WBPaper00056169:rrf-3(pk1426)_downregulated_L4 |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L2 |
| | | WBPaper00056290:hsp-6(mg585)_upregulated |
| | | WBPaper00056290:mdt-15(mg584)_upregulated |
| | | WBPaper00056330:glycine_downregulated |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056586:kri-1(ok1251)_upregulated |
| | | WBPaper00057041:spc-1(cas971)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058927:high-redox-state_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_OP50 |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059191:hsp-16.2p-LIN-29_upregulated |
| | | WBPaper00059231:alh-6(lax105)_L4_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-1(m40)_upregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059605:mut-16(pk710)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059739:hira-1(gk835598)_upregulated_adult |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060273:vrk-1(RNAi)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L4 |
| | | WBPaper00060526:plp-1(ok2155)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:HB115_upregulated |
| | | WBPaper00061007:M.braciatum_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061081:skpo-1(ok1640)_upregulated_OP50 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AMso |
| | | WBPaper00061340:ant_arc_V |
| | | WBPaper00061340:hyp1V_and_ant_arc_V |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILso |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:mlt-9_22518-F33D4.6_14044 |
| | | WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061653:alh-4(hj221)_downregulated |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062118:neural-HSF-1_downregulated |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062456:doxycycline_upregulated_N2_protein |
| | | WBPaper00062456:doxycycline_upregulated_N2_transcript |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062534:fat-P-80_downregulated |
| | | WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_downregulated_EGCs |
| | | WBPaper00064532:pals-25(icb98)_downregulated |
| | | WBPaper00064539:nhr-114(gk849)_downregulated |
| | | WBPaper00064632:daf-2(e1370)_upregulated_intestine |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064728:cpl-1(W32AY35A)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_25C |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065288:mdt-15(tm2182)_upregulated |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065746:eat-2(ad1113)_downregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:34_1 |
| | | WBPaper00065841:82_0 |
| | | WBPaper00065841:82_1 |
| | | WBPaper00065841:132_0 |
| | | WBPaper00065841:140_0 |
| | | WBPaper00065984:pals-17(syb3980)_downregulated |
| | | WBPaper00066004:tdp-1(csb38)_upregulated |
| | | WBPaper00066093:E.coli-purE_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | WBPaper00066410:mbl-1(syb4345)_upregulated |
| | | WBPaper00066485:ogt-1_upregulated_neuron |
| | | cgc4489_group_8 |
| | | WBPaper00026929:Resveratrol_regulated_N2 |
| | | WBPaper00026952:class_E |
| | | WBPaper00028948:cep-1(gk138)+UV_downregulated |
| | | WBPaper00031703:heme_responsive_4 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00032948:MoltOssilate |
| | | WBPaper00033101:spr-5_regulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037113:CPF_16C_down-regulated |
| | | WBPaper00038060:SUMO-1_downregulated |
| | | WBPaper00038172:crh-1null_down_regulated |
| | | WBPaper00038172:tax-6null_down_regulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040116:pRJ-FR.5_down_regulated |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00041207:CE_dauer_down |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042258:DA1877_downregulated_YoungAdult |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045437:Toxic-Se_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046083:oga-1(ok1207)_OP50_downregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_downregulated |
| | | WBPaper00047070:N2_starvation_downregulated |
| | | WBPaper00047070:N2_UV_downregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_upregulated |
| | | [cgc6390]:Cluster_C |
| | Interaction (139) |
| | WBProcess | WBbiopr:00000123 |
| Map_info | Map | X | Position | -10.3063 | Error | 0.01522 |
| | Positive | Positive_clone | ZK377 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4357 |
| | | | 4758 |
| | Pseudo_map_position |
| Reference (19) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
