| WBGene00006942 | SMap | S_parent | Sequence | F41D9 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | wrk-1 | Person_evidence | WBPerson260 |
| | | Sequence_name | F41D9.3 |
| | | Molecular_name (15) |
| | | Other_name | CELE_F41D9.3 | Accession_evidence | NDB | BX284606 |
| | | Public_name | wrk-1 |
| | DB_info | Database | AceView | gene | XJ6 |
| | | | WormQTL | gene | WBGene00006942 |
| | | | WormFlux | gene | WBGene00006942 |
| | | | NDB | locus_tag | CELE_F41D9.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006942|UniProtKB=Q5WRR1 |
| | | | | family | PTHR45080 |
| | | | NCBI | gene | 181093 |
| | | | RefSeq | protein | NM_001029478.5 |
| | | | | | NM_001029480.6 |
| | | | | | NM_001029477.6 |
| | | | | | NM_001373391.4 |
| | | | | | NM_001029476.4 |
| | | | TREEFAM | TREEFAM_ID | TF325699 |
| | | | TrEMBL | UniProtAcc | H2KZN8 |
| | | | | | H2KZN9 |
| | | | | | A0A4V0ING2 |
| | | | | | Q8MPV0 |
| | | | | | Q5WRR1 |
| | | | UniProt_GCRP | UniProtAcc | Q5WRR1 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | wrk |
| | Allele (104) |
| | Strain (20) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00003700 |
| | | 00003701 |
| | | 00003702 |
| | | 00003703 |
| | | 00003704 |
| | | 00003705 |
| | | 00003706 |
| | | 00003707 |
| | Ortholog (34) |
| | Paralog | WBGene00004372 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | wrk-1 encodes, by alternative splicing, at least three isoforms of aGPI-anchored immunoglobulin superfamily (IgSF) protein orthologous toDrosophila KLINGON, WRAPPER, CG7166, and CG13506; WRK-1 is expressed inthe pioneering embryonic motoneurons (eMNs) DA, DB, and DD; WRK-1expression in DA, DB, and DD is necessary and sufficient to preventfollower axons from inappropriately crossing the ventral midline; WRK-1also retards developmental changes in the outward current of maturingAIY interneurons; in addition to eMNs and AIY neurons, WRK-1 isexpressed in ASI and SMDV/D neurons, along with sheath and socket cells,intestine, the excretory gland cell, distal tip cells, and coelomocytes;wrk-1 transcription in AIY requires TTX-3, being greatly reduced in attx-3(ot22) mutant background; however, wrk-1 may not betranscriptionally activated by CEH-10/TTX-3 heterodimers, since wrk-1 lacks an AIY motif in its cis-regulatory sequences; WRK-1 binds VAB-1 orVAB-2 in vitro, and wrk-1(ok695) mutations fail to enhance vab-1 or atriple vab-2, efn-2, and efn-3 mutation, indicating that WRK-1 acts in concert with ephrins; wrk-1(ok695) null mutants exhibit midlinecrossover defects in the axons of HSN, PVQ, AV-type, and PVC neurons;wrk-1(ok695) and wrk-1(tm1099) mutant neurons have normal whole cellcapacitance but precociously altered their outward current from a slowlyactivating, sustained current to a rapidly-activating one; hypodermal misexpression of WRK-1 induces defects in PVQ axonal outgrowth, which are enhanced by a wrk-1(ok695) mutant background; wrk-1(ok695) mutationsenhance sax-3(ky123), indicating that WRK-1 and SAX-3 act in parallel. | Paper_evidence | WBPaper00005064 |
| | | | | | WBPaper00024232 |
| | | | | | WBPaper00027182 |
| | | | | | WBPaper00028566 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | | WBPerson1843 |
| | | | | Date_last_updated | 07 Jan 2008 00:00:00 |
| | | Automated_description | Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including SMDVL; body ganglion; head neurons; hermaphrodite distal tip cell; and interfacial epithelial cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase |
| | | | | Date_last_updated | 24 Apr 2024 00:00:00 |
| Molecular_info | Corresponding_CDS | F41D9.3a |
| | | F41D9.3b |
| | | F41D9.3c |
| | | F41D9.3e |
| | | F41D9.3f |
| | Corresponding_CDS_history | F41D9.3d:wp271 |
| | Corresponding_transcript | F41D9.3a.1 |
| | | F41D9.3b.1 |
| | | F41D9.3c.1 |
| | | F41D9.3e.1 |
| | | F41D9.3f.1 |
| | Other_sequence | JI167162.1 |
| | | CBC16075_1 |
| | | Acan_isotig08406 |
| | | Tcol_isotig17069 |
| | Associated_feature (22) |
| Experimental_info | RNAi_result | WBRNAi00046984 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00014740 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090689 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1761 |
| | | Expr4281 |
| | | Expr7829 |
| | | Expr8842 |
| | | Expr13214 |
| | | Expr1012620 |
| | | Expr1032956 |
| | | Expr1150847 |
| | | Expr2018072 |
| | | Expr2036210 |
| | Drives_construct | WBCnstr00001442 |
| | | WBCnstr00001443 |
| | | WBCnstr00001444 |
| | | WBCnstr00001497 |
| | | WBCnstr00001530 |
| | | WBCnstr00013552 |
| | | WBCnstr00034084 |
| | Construct_product | WBCnstr00001497 |
| | | WBCnstr00006614 |
| | | WBCnstr00034084 |
| | Microarray_results (43) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_CoreEnriched |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_larva_enriched |
| | | WBPaper00037950:coelomocytes_larva_SelectivelyEnriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040722:GPI-anchored_protein |
| | | WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster5 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053814:25C_downregulated_OP50 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056284:ints-5(RNAi)_upregulated |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059440:LAG-1_repressed_4hr-auxin |
| | | WBPaper00059440:LAG-1_repressed_48hr-auxin |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061274:hypergravity_10xg_downregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:Anterior_arcade_cell |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:hyp1_hyp2 |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Neuroblast_ALM_BDU |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVR |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061341:28C_24h_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:ldb-1_2877-scd-1_3086 |
| | | WBPaper00061527:Y37D8A.16-F54D1.6_15313 |
| | | WBPaper00061651:Coelomocyte_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064122:vulva_transcriptome |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064532:pals-25(icb98)_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:12_0 |
| | | WBPaper00065841:92_0 |
| | | WBPaper00065877:rege-1(imm070)_upregulated_OP50 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066160:cua-1(knu790)_upregulated |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4386_cluster_5_3 |
| | | WBPaper00025032:cluster_74 |
| | | WBPaper00025032:cluster_168 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00037695:WC_5-day |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_0.2mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(122_min) |
| | Interaction (21) |
| Map_info | Map | X | Position | -0.140944 | Error | 0.004413 |
| | Positive | Positive_clone | F41D9 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4755 |
| | | | 4975 |
| | | | 5631 |
| | Pseudo_map_position |
| Reference (15) |
| Remark | Sequence connection from [Hobert O] |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
