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WormBase Tree Display for Gene: WBGene00003885

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Name Class

WBGene00003885EvidenceCGC_data_submission
SMapS_parentSequenceY41G9A
IdentityVersion1
NameCGC_nameosm-5Person_evidenceWBPerson242
Sequence_nameY41G9A.1
Molecular_nameY41G9A.1
Y41G9A.1.1
CE28361
Other_nameCELE_Y41G9A.1Accession_evidenceNDBBX284606
Public_nameosm-5
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:898Homo sapiensPaper_evidenceWBPaper00004603
WBPaper00004715
Accession_evidenceOMIM173900
Curator_confirmedWBPerson324
Date_last_updated30 Apr 2018 00:00:00
Disease_relevanceStudies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; osm-5 is orthologous to the murine polycystic kidney disease gene Tg737, which encodes the protein Polaris and human IFT88; both polaris and OSM-5 have the tetratricopeptide repeat (TPT), a motif that mediates protein-protein interactions; the association of pathologies in mice mutant for Tg737 with ciliary defects in the kidney cells and studies in elegans that demonstrate that osm-5 is expressed and migrates within cilia, substantiate a ciliogenic role for polaris and osm-5, possibly as components of the intraflagellar transport (IFT) system; osm-5 is also required for correct ciliary targeting of lov-1 and pkd-2, genes that are orthologous to human PKD1 and PKD2, which are mutated in human autosomal dominant polycystic kidney disease.Homo sapiensPaper_evidenceWBPaper00004603
Curator_confirmedWBPerson324
Date_last_updated31 Jan 2013 00:00:00
Models_disease_in_annotationWBDOannot00000030
Models_disease_assertedWBDOannot00000513
Molecular_infoCorresponding_CDSY41G9A.1
Corresponding_transcriptY41G9A.1.1
Other_sequence (25)
Associated_feature (12)
Experimental_infoRNAi_resultWBRNAi00095205Inferred_automaticallyRNAi_primary
WBRNAi00056418Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_construct (12)
Construct_productWBCnstr00006237
WBCnstr00008467
WBCnstr00009069
WBCnstr00010229
WBCnstr00013368
WBCnstr00039933
AntibodyWBAntibody00000351
WBAntibody00001248
Microarray_results (19)
Expression_clusterWBPaper00032976:dosage_compensated_genes
WBPaper00037950:all-neurons_CoreEnriched
WBPaper00037950:all-neurons_embryo_enriched
WBPaper00037950:all-neurons_embryo_SelectivelyEnriched
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_SelectivelyEnriched
WBPaper00037950:BAG-neuron_embryo_enriched
WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
WBPaper00037950:dopaminergic-neurons_CoreEnriched
WBPaper00037950:dopaminergic-neurons_embryo_enriched
WBPaper00037950:dopaminergic-neurons_embryo_SelectivelyEnriched
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
WBPaper00038061:aldicarb_upregulated
WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
WBPaper00044736:flat_dev_expression
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045861:ash-2(tm1095)_upregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049001:EVN_enriched
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050332:skn-1(RNAi)_downregulated
WBPaper00050344:ASER-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
WBPaper00050843:sesamin_downregulated
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055226:ADR-2_target_adr-1(tm668)
WBPaper00055226:ADR-2_target_N2
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056161:male_enriched_siRNA
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:set-2(bn129)_upregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059027:neuron-synapses_depleted
WBPaper00059117:B.subtilis_upregulated
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059739:hira-1(gk835598)_upregulated_L1
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060764:swsn-9(ok1354)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ADE
WBPaper00061340:ADF
WBPaper00061340:ADF_AWB
WBPaper00061340:ADL
WBPaper00061340:AFD
WBPaper00061340:ASE
WBPaper00061340:ASE_parent
WBPaper00061340:ASG
WBPaper00061340:ASG_AWA
WBPaper00061340:ASH
WBPaper00061340:ASI
WBPaper00061340:ASI_parent
WBPaper00061340:ASJ
WBPaper00061340:ASK
WBPaper00061340:ASK_parent
WBPaper00061340:AUA
WBPaper00061340:AWA
WBPaper00061340:AWB
WBPaper00061340:AWC
WBPaper00061340:BAG
WBPaper00061340:CEP
WBPaper00061340:IL1
WBPaper00061340:IL1_parent
WBPaper00061340:IL2
WBPaper00061340:Neuroblast_ADE_ADA
WBPaper00061340:Neuroblast_ASG_AWA
WBPaper00061340:Neuroblast_HSN_PHB
WBPaper00061340:Neuroblast_URX_CEPDx
WBPaper00061340:OLL
WBPaper00061340:OLL_parent
WBPaper00061340:OLQ
WBPaper00061340:OLQ_parent
WBPaper00061340:URX
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:rab-28-jbts-14_9542
WBPaper00061651:ADE_enriched
WBPaper00061651:ADF_enriched
WBPaper00061651:ADL_enriched
WBPaper00061651:AQR_enriched
WBPaper00061651:ASG_enriched
WBPaper00061651:ASJ_enriched
WBPaper00061651:ASK_enriched
WBPaper00061651:CEP_enriched
WBPaper00061651:PDE_enriched
WBPaper00061651:PHA_enriched
WBPaper00061651:PHB_enriched
WBPaper00061651:PQR_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062056:efl-1(se1)_upregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062197:mec-8_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064532:pals-22(jy3)_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064735:mys-1(RNAi)_vs_N2_upregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065158:AFD_enriched
WBPaper00065560:E.coli-HB101_downregulated_F3
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065841:25_0
WBPaper00065841:25_1
WBPaper00065841:36_0
WBPaper00065841:36_2
WBPaper00065841:36_3
WBPaper00065841:39_0
WBPaper00065841:39_1
WBPaper00065841:39_2
WBPaper00065841:39_3
WBPaper00065841:44_0
WBPaper00065841:44_1
WBPaper00065841:47_0
WBPaper00065841:71_0
WBPaper00065841:72_0
WBPaper00065841:100_0
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00034739:N2moreDR1350
WBPaper00039866:ClassComp_daf-19_downregulated
WBPaper00039866:SAM_daf-19_downregulated
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041174:environmental
WBPaper00041174:environmental_prime
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045673:colistin_upregulated
WBPaper00046548:dafachronic-acid_upregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
WBPaper00053550:daf-19(m86)_downregulated_L1
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (43)
WBProcessWBbiopr:00000001
WBbiopr:00000012
Map_infoMapXPosition-12.6622Error0.00141
Well_ordered
PositivePositive_cloneY41G9AInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point376
377
3384
Multi_point1209
1210
1211
1212
5291
5597
Pos_neg_data3180
5450
Reference (105)
RemarkSequence connection from [Haycroft CG, Thomas JH]
Data extracted from Haycraft et al (2001)
MethodGene