WormBase Tree Display for Gene: WBGene00002078

WBGene00002078 Evidence: Person_evidence: WBPerson1780
      WBPerson2740
  SMap: S_parent: Sequence: ZK742
  Identity: Version: 2
    Name: CGC_name: xpo-1 Person_evidence: WBPerson1780
      Sequence_name: ZK742.1
      Molecular_name: ZK742.1a
        ZK742.1a.1
        CE23467
        ZK742.1b
        CE31142
        ZK742.1a.2
        ZK742.1b.1
      Other_name: imb-4 Person_evidence: WBPerson1160
        CELE_ZK742.1 Accession_evidence: NDB BX284605
      Public_name: xpo-1
    DB_info: Database: AceView gene 5I293
        WormQTL gene WBGene00002078
        WormFlux gene WBGene00002078
        NDB locus_tag CELE_ZK742.1
        Panther gene CAEEL|WormBase=WBGene00002078|UniProtKB=Q23089
          family PTHR11223
        NCBI gene 179160
        RefSeq protein NM_171484.8
            NM_001380696.1
        TREEFAM TREEFAM_ID TF105695
        TrEMBL UniProtAcc Q8MPS6
            Q23089
        UniProt_GCRP UniProtAcc Q23089
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 30 Jan 2008 11:39:14 WBPerson2970 Name_change: CGC_name: xpo-1
                Other_name: imb-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: xpo
    Allele (123)
    Possibly_affected_by: WBVar02157264
    Strain: WBStrain00054782
      WBStrain00055455
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (36)
    Structured_description: Concise_description: xpo-1 encodes exportin-1, an importin-beta-like protein orthologous to Drosophila, vertebrate, and yeast exportin-1/CRM1; XPO-1 is predicted to function as a nuclear export receptor for proteins containing leucine-rich nuclear export signals; in C. elegans, XPO-1 is essential for embryogenesis and larval development, and may also be required for normal body morphology and postembryonic growth rates. Paper_evidence: WBPaper00005654
            WBPaper00013581
            WBPaper00029236
          Curator_confirmed: WBPerson1843
          Date_last_updated: 11 Apr 2008 00:00:00
      Automated_description: Predicted to enable nuclear export signal receptor activity. Predicted to be involved in ribosomal large subunit export from nucleus and ribosomal small subunit export from nucleus. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung adenocarcinoma; and pancreatic cancer. Is an ortholog of human XPO1 (exportin 1). Paper_evidence: WBPaper00065943
            WBPaper00067038
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS296 version of WormBase
          Date_last_updated: 20 Mar 2025 00:00:00
  Disease_info: Potential_model (11)
  Modifies_disease: DOID:10652
  Modifies_disease_in_annotation: WBDOannot00000727
  Molecular_info: Corresponding_CDS: ZK742.1a
      ZK742.1b
    Corresponding_transcript: ZK742.1a.1
      ZK742.1a.2
      ZK742.1b.1
    Other_sequence (63)
    Associated_feature (11)
  Experimental_info: RNAi_result (32)
    Expr_pattern: Expr1012777
      Expr1031231
      Expr1163110
      Expr2018106
      Expr2036244
    Drives_construct: WBCnstr00037964
    Construct_product: WBCnstr00037964
    Regulate_expr_cluster: WBPaper00064158:xpo-1(RNAi)_downregulated
      WBPaper00064158:xpo-1(RNAi)_upregulated
    Microarray_results (38)
    Expression_cluster: WBPaper00028451:Oogenic_protein
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00034761:hlh-30_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_larva_enriched
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:coelomocytes_larva_enriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042552:daf-2(e1370)_downregulated_daf-16-dependent
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046012:tdp-1(ok803)_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059174:MEG-3_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:trcs-2_5724-R11A8.7_17645
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064158:xpo-1(RNAi)_downregulated
      WBPaper00064201:SNA-3_interacting
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:bet-1B(OE)mys-1(RNAi)_vs_mys-1(RNAi)_upregulated
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:25C_vs_15C_upregulated_AFD
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00066418:pri-1(RNAi)_upregulated
      WBPaper00066594:ilc-17.1(syb5296)_upregulated
      WBPaper00066618:fmi-1(rh308)_downregulated
      WBPaper00066679:let-767(RNAi)_upregulated
      WBPaper00066880:gonad_expressed
      WBPaper00066880:intestine_expressed
      WBPaper00067024:Amyloid-Beta_induced_insoluble_protein
      WBPaper00067044:lin-53(RNAi)_upregulated
      WBPaper00067147:germline_expressed
      cgc4489_group_1
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00005124:testosterone_10-9M_regulated
      WBPaper00025032:cluster_13
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rrf-2(ok210)_upregulated
      WBPaper00031832:slr-2_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_downregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00051387:Triclosan_upregulated
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      [cgc6390]:Cluster_F
      [cgc6390]:oogenesis-enriched
    Interaction (158)
    WBProcess: WBbiopr:00000081
  Map_info: Map: V Position: 0.910819 Error: 0.000238
    Positive: Positive_clone: ZK742 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (34)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene